node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALB | LEFTY2 | ENSP00000295897 | ENSP00000355785 | albumin | left-right determination factor 2; Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding | 0.910 |
ALB | SERPINE1 | ENSP00000295897 | ENSP00000223095 | albumin | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Serine protease inhibitor. This inhibitor acts as ’bait’ for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis | 0.993 |
ALB | SPARC | ENSP00000295897 | ENSP00000231061 | albumin | secreted protein, acidic, cysteine-rich (osteonectin); Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity | 0.947 |
ALB | TGFB1 | ENSP00000295897 | ENSP00000221930 | albumin | transforming growth factor, beta 1; Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts | 0.963 |
ALB | TGFB2 | ENSP00000295897 | ENSP00000355896 | albumin | transforming growth factor, beta 2; TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth | 0.927 |
ALB | TGFB3 | ENSP00000295897 | ENSP00000238682 | albumin | transforming growth factor, beta 3; Involved in embryogenesis and cell differentiation | 0.931 |
ALB | TIMP1 | ENSP00000295897 | ENSP00000218388 | albumin | TIMP metallopeptidase inhibitor 1; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14 | 0.962 |
ALB | VEGFA | ENSP00000295897 | ENSP00000361125 | albumin | vascular endothelial growth factor A | 0.964 |
LEFTY2 | ALB | ENSP00000355785 | ENSP00000295897 | left-right determination factor 2; Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding | albumin | 0.910 |
LEFTY2 | NODAL | ENSP00000355785 | ENSP00000287139 | left-right determination factor 2; Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding | nodal homolog (mouse); Essential for mesoderm formation and axial patterning during embryonic development (By similarity) | 0.984 |
LEFTY2 | PITX2 | ENSP00000355785 | ENSP00000304169 | left-right determination factor 2; Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding | paired-like homeodomain 2; Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach. Isoform PTX2C is involved in left-right asymmetry the developing embryo (By similarity) | 0.924 |
LEFTY2 | SERPINE1 | ENSP00000355785 | ENSP00000223095 | left-right determination factor 2; Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Serine protease inhibitor. This inhibitor acts as ’bait’ for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis | 0.910 |
LEFTY2 | SPARC | ENSP00000355785 | ENSP00000231061 | left-right determination factor 2; Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding | secreted protein, acidic, cysteine-rich (osteonectin); Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity | 0.911 |
LEFTY2 | TGFB1 | ENSP00000355785 | ENSP00000221930 | left-right determination factor 2; Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding | transforming growth factor, beta 1; Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts | 0.938 |
LEFTY2 | TGFB2 | ENSP00000355785 | ENSP00000355896 | left-right determination factor 2; Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding | transforming growth factor, beta 2; TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth | 0.918 |
LEFTY2 | TGFB3 | ENSP00000355785 | ENSP00000238682 | left-right determination factor 2; Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding | transforming growth factor, beta 3; Involved in embryogenesis and cell differentiation | 0.922 |
LEFTY2 | TIMP1 | ENSP00000355785 | ENSP00000218388 | left-right determination factor 2; Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding | TIMP metallopeptidase inhibitor 1; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14 | 0.913 |
LEFTY2 | VEGFA | ENSP00000355785 | ENSP00000361125 | left-right determination factor 2; Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding | vascular endothelial growth factor A | 0.916 |
NODAL | LEFTY2 | ENSP00000287139 | ENSP00000355785 | nodal homolog (mouse); Essential for mesoderm formation and axial patterning during embryonic development (By similarity) | left-right determination factor 2; Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding | 0.984 |
NODAL | PITX2 | ENSP00000287139 | ENSP00000304169 | nodal homolog (mouse); Essential for mesoderm formation and axial patterning during embryonic development (By similarity) | paired-like homeodomain 2; Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach. Isoform PTX2C is involved in left-right asymmetry the developing embryo (By similarity) | 0.451 |