node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GPR37 | PARK2 | ENSP00000306449 | ENSP00000355865 | G protein-coupled receptor 37 (endothelin receptor type B-like); Orphan receptor. May have a unique functional role in the central nervous system | parkinson protein 2, E3 ubiquitin protein ligase (parkin) | 0.999 |
GPR37 | PINK1 | ENSP00000306449 | ENSP00000364204 | G protein-coupled receptor 37 (endothelin receptor type B-like); Orphan receptor. May have a unique functional role in the central nervous system | PTEN induced putative kinase 1; Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitment to dysfunctional mitochondria to initiate their degradation | 0.564 |
GPR37 | SNCAIP | ENSP00000306449 | ENSP00000261368 | G protein-coupled receptor 37 (endothelin receptor type B-like); Orphan receptor. May have a unique functional role in the central nervous system | synuclein, alpha interacting protein | 0.743 |
GPR37 | UBC | ENSP00000306449 | ENSP00000344818 | G protein-coupled receptor 37 (endothelin receptor type B-like); Orphan receptor. May have a unique functional role in the central nervous system | ubiquitin C | 0.862 |
GPR37 | UBE2G1 | ENSP00000306449 | ENSP00000380178 | G protein-coupled receptor 37 (endothelin receptor type B-like); Orphan receptor. May have a unique functional role in the central nervous system | ubiquitin-conjugating enzyme E2G 1; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys- 48’-, as well as ’Lys-63’-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4 | 0.900 |
GPR37 | UBE2G2 | ENSP00000306449 | ENSP00000338348 | G protein-coupled receptor 37 (endothelin receptor type B-like); Orphan receptor. May have a unique functional role in the central nervous system | ubiquitin-conjugating enzyme E2G 2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys- 48’-linked polyubiquitination. Involved in endoplasmic reticulum- associated degradation (ERAD) | 0.900 |
GPR37 | UBE2L3 | ENSP00000306449 | ENSP00000344259 | G protein-coupled receptor 37 (endothelin receptor type B-like); Orphan receptor. May have a unique functional role in the central nervous system | ubiquitin-conjugating enzyme E2L 3; Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine- in contrast, it has activity with the RBR family E3 enzymes, such as PARK2 and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys-11’-linked polyubiquitination. Involved in th [...] | 0.416 |
PARK2 | GPR37 | ENSP00000355865 | ENSP00000306449 | parkinson protein 2, E3 ubiquitin protein ligase (parkin) | G protein-coupled receptor 37 (endothelin receptor type B-like); Orphan receptor. May have a unique functional role in the central nervous system | 0.999 |
PARK2 | PINK1 | ENSP00000355865 | ENSP00000364204 | parkinson protein 2, E3 ubiquitin protein ligase (parkin) | PTEN induced putative kinase 1; Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitment to dysfunctional mitochondria to initiate their degradation | 0.999 |
PARK2 | PSMD4 | ENSP00000355865 | ENSP00000357879 | parkinson protein 2, E3 ubiquitin protein ligase (parkin) | proteasome (prosome, macropain) 26S subunit, non-ATPase, 4; Binds and presumably selects ubiquitin-conjugates for destruction. Displays selectivity for longer polyubiquitin chains. Modulates intestinal fluid secretion | 0.998 |
PARK2 | SNCA | ENSP00000355865 | ENSP00000338345 | parkinson protein 2, E3 ubiquitin protein ligase (parkin) | synuclein, alpha (non A4 component of amyloid precursor); May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation | 0.999 |
PARK2 | SNCAIP | ENSP00000355865 | ENSP00000261368 | parkinson protein 2, E3 ubiquitin protein ligase (parkin) | synuclein, alpha interacting protein | 0.999 |
PARK2 | UBC | ENSP00000355865 | ENSP00000344818 | parkinson protein 2, E3 ubiquitin protein ligase (parkin) | ubiquitin C | 0.999 |
PARK2 | UBE2G1 | ENSP00000355865 | ENSP00000380178 | parkinson protein 2, E3 ubiquitin protein ligase (parkin) | ubiquitin-conjugating enzyme E2G 1; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys- 48’-, as well as ’Lys-63’-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4 | 0.996 |
PARK2 | UBE2G2 | ENSP00000355865 | ENSP00000338348 | parkinson protein 2, E3 ubiquitin protein ligase (parkin) | ubiquitin-conjugating enzyme E2G 2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys- 48’-linked polyubiquitination. Involved in endoplasmic reticulum- associated degradation (ERAD) | 0.997 |
PARK2 | UBE2L3 | ENSP00000355865 | ENSP00000344259 | parkinson protein 2, E3 ubiquitin protein ligase (parkin) | ubiquitin-conjugating enzyme E2L 3; Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine- in contrast, it has activity with the RBR family E3 enzymes, such as PARK2 and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys-11’-linked polyubiquitination. Involved in th [...] | 0.999 |
PARK2 | UBE2N | ENSP00000355865 | ENSP00000316176 | parkinson protein 2, E3 ubiquitin protein ligase (parkin) | ubiquitin-conjugating enzyme E2N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical ’Lys-63’-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the ’Lys-63’-linked poly-ubiquitination of PC [...] | 0.997 |
PINK1 | GPR37 | ENSP00000364204 | ENSP00000306449 | PTEN induced putative kinase 1; Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitment to dysfunctional mitochondria to initiate their degradation | G protein-coupled receptor 37 (endothelin receptor type B-like); Orphan receptor. May have a unique functional role in the central nervous system | 0.564 |
PINK1 | PARK2 | ENSP00000364204 | ENSP00000355865 | PTEN induced putative kinase 1; Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitment to dysfunctional mitochondria to initiate their degradation | parkinson protein 2, E3 ubiquitin protein ligase (parkin) | 0.999 |
PINK1 | SNCA | ENSP00000364204 | ENSP00000338345 | PTEN induced putative kinase 1; Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitment to dysfunctional mitochondria to initiate their degradation | synuclein, alpha (non A4 component of amyloid precursor); May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation | 0.889 |