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SPNS3 SPNS3 CERS2 CERS2 SLC47A2 SLC47A2 SLC22A1 SLC22A1 SLCO1B3 SLCO1B3 ABCB1 ABCB1 ABCG2 ABCG2 SLC47A1 SLC47A1 SLC28A1 SLC28A1 ENSG00000257046 ENSG00000257046 SLCO1B1 SLCO1B1
"SLC22A1" - solute carrier family 22 (organic cation transporter), member 1 in Homo sapiens
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protein of unknown 3D structure
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Predicted Interactions
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SLC22A1solute carrier family 22 (organic cation transporter), member 1; Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)- N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), coca [...] (554 aa)    
Predicted Functional Partners:
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1; Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (1280 aa)
           score_image score_image   0.972
ABCG2
ATP-binding cassette, sub-family G (WHITE), member 2 (655 aa)
         score_image score_image score_image   0.967
CERS2
ceramide synthase 2; Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis (380 aa)
         score_image   score_image   0.903
SLC47A1
solute carrier family 47, member 1; Solute transporter for tetraethylammonium (TEA), 1- methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4’-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membranes (570 aa)
             score_image   0.876
SPNS3
spinster homolog 3 (Drosophila); Sphingolipid transporter (By similarity) (512 aa)
             score_image   0.863
SLC47A2
solute carrier family 47, member 2; Solute transporter for tetraethylammonium (TEA), 1- methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes (602 aa)
             score_image   0.820
ENSG00000257046
Putative solute carrier organic anion transporter family member 1B7; Uncharacterized protein (748 aa)
             score_image   0.769
SLCO1B3
solute carrier organic anion transporter family, member 1B3; Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver (702 aa)
             score_image   0.768
SLC28A1
solute carrier family 28 (sodium-coupled nucleoside transporter), member 1; Sodium-dependent and pyrimidine-selective. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). It also transports the antiviral pyrimidine nucleoside analogs 3’-azido-3’-deoxythymidine (AZT) and 2’,3’-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). It has the following selective i [...] (649 aa)
             score_image   0.767
SLCO1B1
solute carrier organic anion transporter family, member 1B1; Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver (691 aa)
             score_image   0.760
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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