node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COL4A6 | CRYBA4 | ENSP00000361290 | ENSP00000346805 | collagen, type IV, alpha 6 | crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens | 0.900 |
COL4A6 | DEDD2 | ENSP00000361290 | ENSP00000470082 | collagen, type IV, alpha 6 | death effector domain containing 2; May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3 | 0.900 |
COL4A6 | HSBP1 | ENSP00000361290 | ENSP00000392896 | collagen, type IV, alpha 6 | heat shock factor binding protein 1; Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process | 0.900 |
COL4A6 | HSP90AA1 | ENSP00000361290 | ENSP00000335153 | collagen, type IV, alpha 6 | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.903 |
COL4A6 | MRPL18 | ENSP00000361290 | ENSP00000356001 | collagen, type IV, alpha 6 | mitochondrial ribosomal protein L18; Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA | 0.900 |
COL4A6 | RPA2 | ENSP00000361290 | ENSP00000363021 | collagen, type IV, alpha 6 | replication protein A2, 32kDa; Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions. Required for the efficient recruitment of the DNA double-strand break repair factor RAD51 to chromatin in response to DNA damage | 0.900 |
COL4A6 | RPA3 | ENSP00000361290 | ENSP00000223129 | collagen, type IV, alpha 6 | replication protein A3, 14kDa; Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions | 0.900 |
COL4A6 | RPS19BP1 | ENSP00000361290 | ENSP00000333948 | collagen, type IV, alpha 6 | ribosomal protein S19 binding protein 1; Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity | 0.900 |
COL4A6 | SERPINH1 | ENSP00000361290 | ENSP00000350894 | collagen, type IV, alpha 6 | serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1); Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen | 0.903 |
COL4A6 | UBB | ENSP00000361290 | ENSP00000304697 | collagen, type IV, alpha 6 | ubiquitin B | 0.900 |
CRYBA4 | COL4A6 | ENSP00000346805 | ENSP00000361290 | crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens | collagen, type IV, alpha 6 | 0.900 |
CRYBA4 | DEDD2 | ENSP00000346805 | ENSP00000470082 | crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens | death effector domain containing 2; May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3 | 0.900 |
CRYBA4 | HSBP1 | ENSP00000346805 | ENSP00000392896 | crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens | heat shock factor binding protein 1; Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process | 0.900 |
CRYBA4 | HSP90AA1 | ENSP00000346805 | ENSP00000335153 | crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.900 |
CRYBA4 | MRPL18 | ENSP00000346805 | ENSP00000356001 | crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens | mitochondrial ribosomal protein L18; Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA | 0.900 |
CRYBA4 | RPA2 | ENSP00000346805 | ENSP00000363021 | crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens | replication protein A2, 32kDa; Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions. Required for the efficient recruitment of the DNA double-strand break repair factor RAD51 to chromatin in response to DNA damage | 0.900 |
CRYBA4 | RPA3 | ENSP00000346805 | ENSP00000223129 | crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens | replication protein A3, 14kDa; Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions | 0.900 |
CRYBA4 | RPS19BP1 | ENSP00000346805 | ENSP00000333948 | crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens | ribosomal protein S19 binding protein 1; Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity | 0.900 |
CRYBA4 | SERPINH1 | ENSP00000346805 | ENSP00000350894 | crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens | serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1); Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen | 0.900 |
CRYBA4 | UBB | ENSP00000346805 | ENSP00000304697 | crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens | ubiquitin B | 0.900 |