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HK2 HK2 HK1 HK1 AKT1 AKT1 PFKP PFKP FBP2 FBP2 PFKFB2 PFKFB2 PFKL PFKL FBP1 FBP1 PFKM PFKM HK3 HK3 HKDC1 HKDC1
"PFKFB2" - 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
PFKFB26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2; Synthesis and degradation of fructose 2,6-bisphosphate (505 aa)    
Predicted Functional Partners:
AKT1
v-akt murine thymoma viral oncogene homolog 1; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] (480 aa)
      score_image score_image score_image score_image   0.983
PFKM
phosphofructokinase, muscle; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP (851 aa)
          score_image score_image   0.976
PFKL
phosphofructokinase, liver; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP (780 aa)
          score_image score_image   0.960
HK2
hexokinase 2 (917 aa)
          score_image score_image   0.960
PFKP
phosphofructokinase, platelet; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP (784 aa)
          score_image score_image   0.960
HK3
hexokinase 3 (white cell) (923 aa)
          score_image score_image   0.955
FBP2
fructose-1,6-bisphosphatase 2 (339 aa)
          score_image score_image   0.953
FBP1
fructose-1,6-bisphosphatase 1 (338 aa)
          score_image score_image   0.951
HK1
hexokinase 1 (921 aa)
          score_image score_image   0.949
HKDC1
hexokinase domain containing 1 (917 aa)
          score_image score_image   0.946
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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