node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKT1 | HK1 | ENSP00000270202 | ENSP00000384774 | v-akt murine thymoma viral oncogene homolog 1; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] | hexokinase 1 | 0.482 |
AKT1 | HK2 | ENSP00000270202 | ENSP00000290573 | v-akt murine thymoma viral oncogene homolog 1; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] | hexokinase 2 | 0.901 |
AKT1 | PFKFB2 | ENSP00000270202 | ENSP00000356047 | v-akt murine thymoma viral oncogene homolog 1; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2; Synthesis and degradation of fructose 2,6-bisphosphate | 0.983 |
AKT1 | PFKL | ENSP00000270202 | ENSP00000269848 | v-akt murine thymoma viral oncogene homolog 1; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] | phosphofructokinase, liver; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP | 0.905 |
AKT1 | PFKM | ENSP00000270202 | ENSP00000345771 | v-akt murine thymoma viral oncogene homolog 1; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] | phosphofructokinase, muscle; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP | 0.923 |
AKT1 | PFKP | ENSP00000270202 | ENSP00000370517 | v-akt murine thymoma viral oncogene homolog 1; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation o [...] | phosphofructokinase, platelet; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP | 0.902 |
FBP1 | FBP2 | ENSP00000364475 | ENSP00000364486 | fructose-1,6-bisphosphatase 1 | fructose-1,6-bisphosphatase 2 | 0.821 |
FBP1 | HK1 | ENSP00000364475 | ENSP00000384774 | fructose-1,6-bisphosphatase 1 | hexokinase 1 | 0.963 |
FBP1 | HK2 | ENSP00000364475 | ENSP00000290573 | fructose-1,6-bisphosphatase 1 | hexokinase 2 | 0.960 |
FBP1 | HK3 | ENSP00000364475 | ENSP00000292432 | fructose-1,6-bisphosphatase 1 | hexokinase 3 (white cell) | 0.963 |
FBP1 | HKDC1 | ENSP00000364475 | ENSP00000346643 | fructose-1,6-bisphosphatase 1 | hexokinase domain containing 1 | 0.946 |
FBP1 | PFKFB2 | ENSP00000364475 | ENSP00000356047 | fructose-1,6-bisphosphatase 1 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2; Synthesis and degradation of fructose 2,6-bisphosphate | 0.951 |
FBP1 | PFKL | ENSP00000364475 | ENSP00000269848 | fructose-1,6-bisphosphatase 1 | phosphofructokinase, liver; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP | 0.831 |
FBP1 | PFKM | ENSP00000364475 | ENSP00000345771 | fructose-1,6-bisphosphatase 1 | phosphofructokinase, muscle; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP | 0.830 |
FBP1 | PFKP | ENSP00000364475 | ENSP00000370517 | fructose-1,6-bisphosphatase 1 | phosphofructokinase, platelet; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP | 0.824 |
FBP2 | FBP1 | ENSP00000364486 | ENSP00000364475 | fructose-1,6-bisphosphatase 2 | fructose-1,6-bisphosphatase 1 | 0.821 |
FBP2 | HK1 | ENSP00000364486 | ENSP00000384774 | fructose-1,6-bisphosphatase 2 | hexokinase 1 | 0.962 |
FBP2 | HK2 | ENSP00000364486 | ENSP00000290573 | fructose-1,6-bisphosphatase 2 | hexokinase 2 | 0.963 |
FBP2 | HK3 | ENSP00000364486 | ENSP00000292432 | fructose-1,6-bisphosphatase 2 | hexokinase 3 (white cell) | 0.966 |
FBP2 | HKDC1 | ENSP00000364486 | ENSP00000346643 | fructose-1,6-bisphosphatase 2 | hexokinase domain containing 1 | 0.946 |