IL20 protein (Homo sapiens) - STRING network view

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IL20

interleukin 20; Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3 (176 aa)

Predicted Functional Partners:

IL20RA

0.998

IL20RB

0.997

IL22RA1

0.947

IFNGR1

0.862

IL10RA

0.854

IL5RA

0.842

LIFR

0.837

IL28RA

0.836

IFNGR2

0.829

IL1B

0.828

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IFNGR1	IFNGR2	ENSP00000356713	ENSP00000290219	interferon gamma receptor 1; Receptor for interferon gamma. Two receptors bind one interferon gamma dimer	interferon gamma receptor 2 (interferon gamma transducer 1); Part of the receptor for interferon gamma. Required for signal transduction. This accessory factor is an integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2	0.980
IFNGR1	IL20	ENSP00000356713	ENSP00000356063	interferon gamma receptor 1; Receptor for interferon gamma. Two receptors bind one interferon gamma dimer	interleukin 20; Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3	0.862
IFNGR1	IL20RB	ENSP00000356713	ENSP00000328133	interferon gamma receptor 1; Receptor for interferon gamma. Two receptors bind one interferon gamma dimer	interleukin 20 receptor beta; The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24	0.440
IFNGR1	IL22RA1	ENSP00000356713	ENSP00000270800	interferon gamma receptor 1; Receptor for interferon gamma. Two receptors bind one interferon gamma dimer	interleukin 22 receptor, alpha 1; Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation	0.560
IFNGR2	IFNGR1	ENSP00000290219	ENSP00000356713	interferon gamma receptor 2 (interferon gamma transducer 1); Part of the receptor for interferon gamma. Required for signal transduction. This accessory factor is an integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2	interferon gamma receptor 1; Receptor for interferon gamma. Two receptors bind one interferon gamma dimer	0.980
IFNGR2	IL20	ENSP00000290219	ENSP00000356063	interferon gamma receptor 2 (interferon gamma transducer 1); Part of the receptor for interferon gamma. Required for signal transduction. This accessory factor is an integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2	interleukin 20; Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3	0.829
IL10RA	IL20	ENSP00000227752	ENSP00000356063	interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity	interleukin 20; Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3	0.854
IL10RA	IL20RB	ENSP00000227752	ENSP00000328133	interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity	interleukin 20 receptor beta; The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24	0.465
IL10RA	IL22RA1	ENSP00000227752	ENSP00000270800	interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity	interleukin 22 receptor, alpha 1; Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation	0.964
IL10RA	IL28RA	ENSP00000227752	ENSP00000327824	interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity	interleukin 28 receptor, alpha (interferon, lambda receptor); The IFNLR1/IL10RB dimer is a receptor for IFNL1, IFNL2 and IFNL3. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems not to be essential for early virus- activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium	0.502
IL1B	IL20	ENSP00000263341	ENSP00000356063	interleukin 1, beta; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells	interleukin 20; Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3	0.828
IL20	IFNGR1	ENSP00000356063	ENSP00000356713	interleukin 20; Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3	interferon gamma receptor 1; Receptor for interferon gamma. Two receptors bind one interferon gamma dimer	0.862
IL20	IFNGR2	ENSP00000356063	ENSP00000290219	interleukin 20; Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3	interferon gamma receptor 2 (interferon gamma transducer 1); Part of the receptor for interferon gamma. Required for signal transduction. This accessory factor is an integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2	0.829
IL20	IL10RA	ENSP00000356063	ENSP00000227752	interleukin 20; Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3	interleukin 10 receptor, alpha; Receptor for IL10; binds IL10 with a high affinity	0.854
IL20	IL1B	ENSP00000356063	ENSP00000263341	interleukin 20; Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3	interleukin 1, beta; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells	0.828
IL20	IL20RA	ENSP00000356063	ENSP00000314976	interleukin 20; Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3	interleukin 20 receptor, alpha; The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26	0.998
IL20	IL20RB	ENSP00000356063	ENSP00000328133	interleukin 20; Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3	interleukin 20 receptor beta; The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24	0.997
IL20	IL22RA1	ENSP00000356063	ENSP00000270800	interleukin 20; Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3	interleukin 22 receptor, alpha 1; Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation	0.947
IL20	IL28RA	ENSP00000356063	ENSP00000327824	interleukin 20; Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3	interleukin 28 receptor, alpha (interferon, lambda receptor); The IFNLR1/IL10RB dimer is a receptor for IFNL1, IFNL2 and IFNL3. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems not to be essential for early virus- activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium	0.836
IL20	IL5RA	ENSP00000356063	ENSP00000256452	interleukin 20; Cytokine that may be involved in epidermal function and psoriasis. Acts through STAT3	interleukin 5 receptor, alpha; This is the receptor for interleukin-5. The alpha chain binds to IL5	0.842

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