| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ALOX5 | MAPKAPK2 | ENSP00000363512 | ENSP00000356070 | arachidonate 5-lipoxygenase; Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes | mitogen-activated protein kinase-activated protein kinase 2 | 0.963 |
| ARPC5 | MAPKAPK2 | ENSP00000352918 | ENSP00000356070 | actin related protein 2/3 complex, subunit 5, 16kDa; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks | mitogen-activated protein kinase-activated protein kinase 2 | 0.917 |
| CREB1 | HSPB1 | ENSP00000387699 | ENSP00000248553 | cAMP responsive element binding protein 1; Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells | heat shock 27kDa protein 1 | 0.481 |
| CREB1 | HSPB2 | ENSP00000387699 | ENSP00000457706 | cAMP responsive element binding protein 1; Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells | HSPB2-C11orf52 readthrough (non-protein coding); May regulate the kinase DMPK | 0.472 |
| CREB1 | HSPB3 | ENSP00000387699 | ENSP00000303394 | cAMP responsive element binding protein 1; Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells | heat shock 27kDa protein 3; Inhibitor of actin polymerization | 0.444 |
| CREB1 | MAPK14 | ENSP00000387699 | ENSP00000229794 | cAMP responsive element binding protein 1; Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells | mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] | 0.999 |
| CREB1 | MAPKAPK2 | ENSP00000387699 | ENSP00000356070 | cAMP responsive element binding protein 1; Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells | mitogen-activated protein kinase-activated protein kinase 2 | 0.977 |
| CREB1 | TCF3 | ENSP00000387699 | ENSP00000262965 | cAMP responsive element binding protein 1; Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells | transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47); Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue- specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E- box motifs- 5’-CANNTG-3’. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region | 0.465 |
| EZR | MAPK14 | ENSP00000338934 | ENSP00000229794 | ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis | mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] | 0.878 |
| EZR | MAPKAPK2 | ENSP00000338934 | ENSP00000356070 | ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis | mitogen-activated protein kinase-activated protein kinase 2 | 0.895 |
| HNRNPA0 | MAPKAPK2 | ENSP00000316042 | ENSP00000356070 | heterogeneous nuclear ribonucleoprotein A0; mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post- transcriptional regulation of cytokines mRNAs | mitogen-activated protein kinase-activated protein kinase 2 | 0.968 |
| HSPB1 | CREB1 | ENSP00000248553 | ENSP00000387699 | heat shock 27kDa protein 1 | cAMP responsive element binding protein 1; Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells | 0.481 |
| HSPB1 | MAPK14 | ENSP00000248553 | ENSP00000229794 | heat shock 27kDa protein 1 | mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] | 0.994 |
| HSPB1 | MAPKAPK2 | ENSP00000248553 | ENSP00000356070 | heat shock 27kDa protein 1 | mitogen-activated protein kinase-activated protein kinase 2 | 0.993 |
| HSPB2 | CREB1 | ENSP00000457706 | ENSP00000387699 | HSPB2-C11orf52 readthrough (non-protein coding); May regulate the kinase DMPK | cAMP responsive element binding protein 1; Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells | 0.472 |
| HSPB2 | HSPB3 | ENSP00000457706 | ENSP00000303394 | HSPB2-C11orf52 readthrough (non-protein coding); May regulate the kinase DMPK | heat shock 27kDa protein 3; Inhibitor of actin polymerization | 0.648 |
| HSPB2 | MAPK14 | ENSP00000457706 | ENSP00000229794 | HSPB2-C11orf52 readthrough (non-protein coding); May regulate the kinase DMPK | mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] | 0.976 |
| HSPB2 | MAPKAPK2 | ENSP00000457706 | ENSP00000356070 | HSPB2-C11orf52 readthrough (non-protein coding); May regulate the kinase DMPK | mitogen-activated protein kinase-activated protein kinase 2 | 0.986 |
| HSPB3 | CREB1 | ENSP00000303394 | ENSP00000387699 | heat shock 27kDa protein 3; Inhibitor of actin polymerization | cAMP responsive element binding protein 1; Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells | 0.444 |
| HSPB3 | HSPB2 | ENSP00000303394 | ENSP00000457706 | heat shock 27kDa protein 3; Inhibitor of actin polymerization | HSPB2-C11orf52 readthrough (non-protein coding); May regulate the kinase DMPK | 0.648 |
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