NUCKS1 protein (Homo sapiens) - STRING network view

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NUCKS1

nuclear casein kinase and cyclin-dependent kinase substrate 1 (243 aa)

Predicted Functional Partners:

CDK1

0.891

PM20D1

0.815

RAB7L1

0.812

SLC41A1

0.782

ILF3

0.660

SLC45A3

0.660

RBMX

0.644

RBM42

0.644

ORC2

0.644

COPA

0.590

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDK1	NUCKS1	ENSP00000378699	ENSP00000356110	cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl- xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, G [...]	nuclear casein kinase and cyclin-dependent kinase substrate 1	0.891
CDK1	ORC2	ENSP00000378699	ENSP00000234296	cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl- xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, G [...]	origin recognition complex, subunit 2; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication	0.982
COPA	NUCKS1	ENSP00000357048	ENSP00000356110	coatomer protein complex, subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the [...]	nuclear casein kinase and cyclin-dependent kinase substrate 1	0.590
ILF3	NUCKS1	ENSP00000404121	ENSP00000356110	interleukin enhancer binding factor 3, 90kDa	nuclear casein kinase and cyclin-dependent kinase substrate 1	0.660
NUCKS1	CDK1	ENSP00000356110	ENSP00000378699	nuclear casein kinase and cyclin-dependent kinase substrate 1	cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl- xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, G [...]	0.891
NUCKS1	COPA	ENSP00000356110	ENSP00000357048	nuclear casein kinase and cyclin-dependent kinase substrate 1	coatomer protein complex, subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the [...]	0.590
NUCKS1	ILF3	ENSP00000356110	ENSP00000404121	nuclear casein kinase and cyclin-dependent kinase substrate 1	interleukin enhancer binding factor 3, 90kDa	0.660
NUCKS1	ORC2	ENSP00000356110	ENSP00000234296	nuclear casein kinase and cyclin-dependent kinase substrate 1	origin recognition complex, subunit 2; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication	0.644
NUCKS1	PM20D1	ENSP00000356110	ENSP00000356104	nuclear casein kinase and cyclin-dependent kinase substrate 1	peptidase M20 domain containing 1	0.815
NUCKS1	RAB7L1	ENSP00000356110	ENSP00000235932	nuclear casein kinase and cyclin-dependent kinase substrate 1	RAB7, member RAS oncogene family-like 1	0.812
NUCKS1	RBM42	ENSP00000356110	ENSP00000262633	nuclear casein kinase and cyclin-dependent kinase substrate 1	RNA binding motif protein 42; Binds (via the RRM domain) to the 3’-untranslated region (UTR) of CDKN1A mRNA (By similarity)	0.644
NUCKS1	RBMX	ENSP00000356110	ENSP00000359645	nuclear casein kinase and cyclin-dependent kinase substrate 1	RNA binding motif protein, X-linked; RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates [...]	0.644
NUCKS1	SLC41A1	ENSP00000356110	ENSP00000356105	nuclear casein kinase and cyclin-dependent kinase substrate 1	solute carrier family 41, member 1; Acts as a magnesium transporter that is responsive to magnesium balance	0.782
NUCKS1	SLC45A3	ENSP00000356110	ENSP00000356113	nuclear casein kinase and cyclin-dependent kinase substrate 1	solute carrier family 45, member 3	0.660
ORC2	CDK1	ENSP00000234296	ENSP00000378699	origin recognition complex, subunit 2; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication	cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl- xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, G [...]	0.982
ORC2	NUCKS1	ENSP00000234296	ENSP00000356110	origin recognition complex, subunit 2; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication	nuclear casein kinase and cyclin-dependent kinase substrate 1	0.644
PM20D1	NUCKS1	ENSP00000356104	ENSP00000356110	peptidase M20 domain containing 1	nuclear casein kinase and cyclin-dependent kinase substrate 1	0.815
PM20D1	RAB7L1	ENSP00000356104	ENSP00000235932	peptidase M20 domain containing 1	RAB7, member RAS oncogene family-like 1	0.815
PM20D1	SLC41A1	ENSP00000356104	ENSP00000356105	peptidase M20 domain containing 1	solute carrier family 41, member 1; Acts as a magnesium transporter that is responsive to magnesium balance	0.810
PM20D1	SLC45A3	ENSP00000356104	ENSP00000356113	peptidase M20 domain containing 1	solute carrier family 45, member 3	0.664

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