DSTYK protein (Homo sapiens) - STRING network view

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DSTYK

dual serine/threonine and tyrosine protein kinase (929 aa)

Predicted Functional Partners:

PHLPP2

0.819

PHLPP1

0.803

LRGUK

0.688

TAB1

0.674

RAB14

0.662

PPM1F

0.661

PPM1L

0.660

PP2D1

0.660

PPM1E

0.660

PPM1D

0.660

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DSTYK	LRGUK	ENSP00000356130	ENSP00000285928	dual serine/threonine and tyrosine protein kinase	leucine-rich repeats and guanylate kinase domain containing	0.688
DSTYK	PHLPP1	ENSP00000356130	ENSP00000262719	dual serine/threonine and tyrosine protein kinase	PH domain and leucine rich repeat protein phosphatase 1; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads [...]	0.803
DSTYK	PHLPP2	ENSP00000356130	ENSP00000348611	dual serine/threonine and tyrosine protein kinase	PH domain and leucine rich repeat protein phosphatase 2; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradati [...]	0.819
DSTYK	PP2D1	ENSP00000356130	ENSP00000373702	dual serine/threonine and tyrosine protein kinase	protein phosphatase 2C-like domain containing 1	0.660
DSTYK	PPM1D	ENSP00000356130	ENSP00000306682	dual serine/threonine and tyrosine protein kinase	protein phosphatase, Mg2+/Mn2+ dependent, 1D; Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates ’Ser-15’ of TP53 and ’Ser-345’ of CHEK1 which contributes to the functional inactivation of these proteins	0.660
DSTYK	PPM1E	ENSP00000356130	ENSP00000312411	dual serine/threonine and tyrosine protein kinase	protein phosphatase, Mg2+/Mn2+ dependent, 1E; Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42	0.660
DSTYK	PPM1F	ENSP00000356130	ENSP00000263212	dual serine/threonine and tyrosine protein kinase	protein phosphatase, Mg2+/Mn2+ dependent, 1F; Dephosphorylates and concomitantly deactivates CaM- kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis	0.661
DSTYK	PPM1L	ENSP00000356130	ENSP00000417659	dual serine/threonine and tyrosine protein kinase	protein phosphatase, Mg2+/Mn2+ dependent, 1L; Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6	0.660
DSTYK	RAB14	ENSP00000356130	ENSP00000362946	dual serine/threonine and tyrosine protein kinase	RAB14, member RAS oncogene family; Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N- cadherin [...]	0.662
DSTYK	TAB1	ENSP00000356130	ENSP00000216160	dual serine/threonine and tyrosine protein kinase	TGF-beta activated kinase 1/MAP3K7 binding protein 1; May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis	0.674
LRGUK	DSTYK	ENSP00000285928	ENSP00000356130	leucine-rich repeats and guanylate kinase domain containing	dual serine/threonine and tyrosine protein kinase	0.688
LRGUK	PHLPP1	ENSP00000285928	ENSP00000262719	leucine-rich repeats and guanylate kinase domain containing	PH domain and leucine rich repeat protein phosphatase 1; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads [...]	0.665
LRGUK	PHLPP2	ENSP00000285928	ENSP00000348611	leucine-rich repeats and guanylate kinase domain containing	PH domain and leucine rich repeat protein phosphatase 2; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradati [...]	0.665
LRGUK	PP2D1	ENSP00000285928	ENSP00000373702	leucine-rich repeats and guanylate kinase domain containing	protein phosphatase 2C-like domain containing 1	0.621
LRGUK	PPM1D	ENSP00000285928	ENSP00000306682	leucine-rich repeats and guanylate kinase domain containing	protein phosphatase, Mg2+/Mn2+ dependent, 1D; Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates ’Ser-15’ of TP53 and ’Ser-345’ of CHEK1 which contributes to the functional inactivation of these proteins	0.621
LRGUK	PPM1E	ENSP00000285928	ENSP00000312411	leucine-rich repeats and guanylate kinase domain containing	protein phosphatase, Mg2+/Mn2+ dependent, 1E; Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42	0.621
LRGUK	PPM1F	ENSP00000285928	ENSP00000263212	leucine-rich repeats and guanylate kinase domain containing	protein phosphatase, Mg2+/Mn2+ dependent, 1F; Dephosphorylates and concomitantly deactivates CaM- kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis	0.621
LRGUK	PPM1L	ENSP00000285928	ENSP00000417659	leucine-rich repeats and guanylate kinase domain containing	protein phosphatase, Mg2+/Mn2+ dependent, 1L; Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6	0.621
LRGUK	TAB1	ENSP00000285928	ENSP00000216160	leucine-rich repeats and guanylate kinase domain containing	TGF-beta activated kinase 1/MAP3K7 binding protein 1; May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis	0.621
PHLPP1	DSTYK	ENSP00000262719	ENSP00000356130	PH domain and leucine rich repeat protein phosphatase 1; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads [...]	dual serine/threonine and tyrosine protein kinase	0.803

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