node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DSTYK | LRGUK | ENSP00000356130 | ENSP00000285928 | dual serine/threonine and tyrosine protein kinase | leucine-rich repeats and guanylate kinase domain containing | 0.688 |
DSTYK | PHLPP1 | ENSP00000356130 | ENSP00000262719 | dual serine/threonine and tyrosine protein kinase | PH domain and leucine rich repeat protein phosphatase 1; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads [...] | 0.803 |
DSTYK | PHLPP2 | ENSP00000356130 | ENSP00000348611 | dual serine/threonine and tyrosine protein kinase | PH domain and leucine rich repeat protein phosphatase 2; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradati [...] | 0.819 |
DSTYK | PP2D1 | ENSP00000356130 | ENSP00000373702 | dual serine/threonine and tyrosine protein kinase | protein phosphatase 2C-like domain containing 1 | 0.660 |
DSTYK | PPM1D | ENSP00000356130 | ENSP00000306682 | dual serine/threonine and tyrosine protein kinase | protein phosphatase, Mg2+/Mn2+ dependent, 1D; Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates ’Ser-15’ of TP53 and ’Ser-345’ of CHEK1 which contributes to the functional inactivation of these proteins | 0.660 |
DSTYK | PPM1E | ENSP00000356130 | ENSP00000312411 | dual serine/threonine and tyrosine protein kinase | protein phosphatase, Mg2+/Mn2+ dependent, 1E; Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42 | 0.660 |
DSTYK | PPM1F | ENSP00000356130 | ENSP00000263212 | dual serine/threonine and tyrosine protein kinase | protein phosphatase, Mg2+/Mn2+ dependent, 1F; Dephosphorylates and concomitantly deactivates CaM- kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis | 0.661 |
DSTYK | PPM1L | ENSP00000356130 | ENSP00000417659 | dual serine/threonine and tyrosine protein kinase | protein phosphatase, Mg2+/Mn2+ dependent, 1L; Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6 | 0.660 |
DSTYK | RAB14 | ENSP00000356130 | ENSP00000362946 | dual serine/threonine and tyrosine protein kinase | RAB14, member RAS oncogene family; Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N- cadherin [...] | 0.662 |
DSTYK | TAB1 | ENSP00000356130 | ENSP00000216160 | dual serine/threonine and tyrosine protein kinase | TGF-beta activated kinase 1/MAP3K7 binding protein 1; May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis | 0.674 |
LRGUK | DSTYK | ENSP00000285928 | ENSP00000356130 | leucine-rich repeats and guanylate kinase domain containing | dual serine/threonine and tyrosine protein kinase | 0.688 |
LRGUK | PHLPP1 | ENSP00000285928 | ENSP00000262719 | leucine-rich repeats and guanylate kinase domain containing | PH domain and leucine rich repeat protein phosphatase 1; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads [...] | 0.665 |
LRGUK | PHLPP2 | ENSP00000285928 | ENSP00000348611 | leucine-rich repeats and guanylate kinase domain containing | PH domain and leucine rich repeat protein phosphatase 2; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradati [...] | 0.665 |
LRGUK | PP2D1 | ENSP00000285928 | ENSP00000373702 | leucine-rich repeats and guanylate kinase domain containing | protein phosphatase 2C-like domain containing 1 | 0.621 |
LRGUK | PPM1D | ENSP00000285928 | ENSP00000306682 | leucine-rich repeats and guanylate kinase domain containing | protein phosphatase, Mg2+/Mn2+ dependent, 1D; Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates ’Ser-15’ of TP53 and ’Ser-345’ of CHEK1 which contributes to the functional inactivation of these proteins | 0.621 |
LRGUK | PPM1E | ENSP00000285928 | ENSP00000312411 | leucine-rich repeats and guanylate kinase domain containing | protein phosphatase, Mg2+/Mn2+ dependent, 1E; Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42 | 0.621 |
LRGUK | PPM1F | ENSP00000285928 | ENSP00000263212 | leucine-rich repeats and guanylate kinase domain containing | protein phosphatase, Mg2+/Mn2+ dependent, 1F; Dephosphorylates and concomitantly deactivates CaM- kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis | 0.621 |
LRGUK | PPM1L | ENSP00000285928 | ENSP00000417659 | leucine-rich repeats and guanylate kinase domain containing | protein phosphatase, Mg2+/Mn2+ dependent, 1L; Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6 | 0.621 |
LRGUK | TAB1 | ENSP00000285928 | ENSP00000216160 | leucine-rich repeats and guanylate kinase domain containing | TGF-beta activated kinase 1/MAP3K7 binding protein 1; May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis | 0.621 |
PHLPP1 | DSTYK | ENSP00000262719 | ENSP00000356130 | PH domain and leucine rich repeat protein phosphatase 1; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads [...] | dual serine/threonine and tyrosine protein kinase | 0.803 |