node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARAF | BRAF | ENSP00000366244 | ENSP00000288602 | v-raf murine sarcoma 3611 viral oncogene homolog; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus | v-raf murine sarcoma viral oncogene homolog B1 | 0.952 |
ARAF | CNKSR3 | ENSP00000366244 | ENSP00000356182 | v-raf murine sarcoma 3611 viral oncogene homolog; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus | CNKSR family member 3; Probably involved in transepithelial sodium transport. Regulates aldosterone-induced and ENaC-mediated sodium transport possibly through regulation of the ERK pathway (By similarity) | 0.838 |
ARAF | HRAS | ENSP00000366244 | ENSP00000309845 | v-raf murine sarcoma 3611 viral oncogene homolog; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.998 |
ARAF | KRAS | ENSP00000366244 | ENSP00000256078 | v-raf murine sarcoma 3611 viral oncogene homolog; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.980 |
ARAF | KSR1 | ENSP00000366244 | ENSP00000323178 | v-raf murine sarcoma 3611 viral oncogene homolog; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus | kinase suppressor of ras 1; Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity | 0.719 |
ARAF | KSR2 | ENSP00000366244 | ENSP00000339952 | v-raf murine sarcoma 3611 viral oncogene homolog; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus | kinase suppressor of ras 2; Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production | 0.711 |
ARAF | NRAS | ENSP00000366244 | ENSP00000358548 | v-raf murine sarcoma 3611 viral oncogene homolog; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus | neuroblastoma RAS viral (v-ras) oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.989 |
ARAF | RAF1 | ENSP00000366244 | ENSP00000251849 | v-raf murine sarcoma 3611 viral oncogene homolog; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus | v-raf-1 murine leukemia viral oncogene homolog 1; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinase [...] | 0.587 |
ARAF | RRAS2 | ENSP00000366244 | ENSP00000256196 | v-raf murine sarcoma 3611 viral oncogene homolog; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus | related RAS viral (r-ras) oncogene homolog 2; It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion | 0.778 |
BRAF | ARAF | ENSP00000288602 | ENSP00000366244 | v-raf murine sarcoma viral oncogene homolog B1 | v-raf murine sarcoma 3611 viral oncogene homolog; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus | 0.952 |
BRAF | CNKSR3 | ENSP00000288602 | ENSP00000356182 | v-raf murine sarcoma viral oncogene homolog B1 | CNKSR family member 3; Probably involved in transepithelial sodium transport. Regulates aldosterone-induced and ENaC-mediated sodium transport possibly through regulation of the ERK pathway (By similarity) | 0.838 |
BRAF | HRAS | ENSP00000288602 | ENSP00000309845 | v-raf murine sarcoma viral oncogene homolog B1 | v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.999 |
BRAF | KRAS | ENSP00000288602 | ENSP00000256078 | v-raf murine sarcoma viral oncogene homolog B1 | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.971 |
BRAF | KSR1 | ENSP00000288602 | ENSP00000323178 | v-raf murine sarcoma viral oncogene homolog B1 | kinase suppressor of ras 1; Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity | 0.994 |
BRAF | KSR2 | ENSP00000288602 | ENSP00000339952 | v-raf murine sarcoma viral oncogene homolog B1 | kinase suppressor of ras 2; Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production | 0.872 |
BRAF | NRAS | ENSP00000288602 | ENSP00000358548 | v-raf murine sarcoma viral oncogene homolog B1 | neuroblastoma RAS viral (v-ras) oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity | 0.998 |
BRAF | RAF1 | ENSP00000288602 | ENSP00000251849 | v-raf murine sarcoma viral oncogene homolog B1 | v-raf-1 murine leukemia viral oncogene homolog 1; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinase [...] | 0.999 |
BRAF | RRAS2 | ENSP00000288602 | ENSP00000256196 | v-raf murine sarcoma viral oncogene homolog B1 | related RAS viral (r-ras) oncogene homolog 2; It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion | 0.497 |
CNKSR3 | ARAF | ENSP00000356182 | ENSP00000366244 | CNKSR family member 3; Probably involved in transepithelial sodium transport. Regulates aldosterone-induced and ENaC-mediated sodium transport possibly through regulation of the ERK pathway (By similarity) | v-raf murine sarcoma 3611 viral oncogene homolog; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus | 0.838 |
CNKSR3 | BRAF | ENSP00000356182 | ENSP00000288602 | CNKSR family member 3; Probably involved in transepithelial sodium transport. Regulates aldosterone-induced and ENaC-mediated sodium transport possibly through regulation of the ERK pathway (By similarity) | v-raf murine sarcoma viral oncogene homolog B1 | 0.838 |