node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AP4S1 | PIGQ | ENSP00000216366 | ENSP00000026218 | adaptor-related protein complex 4, sigma 1 subunit; Subunit of novel type of clathrin- or non-clathrin- associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system | phosphatidylinositol glycan anchor biosynthesis, class Q; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis | 0.429 |
AP4S1 | TMEM134 | ENSP00000216366 | ENSP00000312615 | adaptor-related protein complex 4, sigma 1 subunit; Subunit of novel type of clathrin- or non-clathrin- associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system | transmembrane protein 134 | 0.546 |
AP4S1 | TMEM183A | ENSP00000216366 | ENSP00000356211 | adaptor-related protein complex 4, sigma 1 subunit; Subunit of novel type of clathrin- or non-clathrin- associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system | transmembrane protein 183A | 0.532 |
AP4S1 | UBC | ENSP00000216366 | ENSP00000344818 | adaptor-related protein complex 4, sigma 1 subunit; Subunit of novel type of clathrin- or non-clathrin- associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system | ubiquitin C | 0.656 |
CH25H | TMEM134 | ENSP00000360918 | ENSP00000312615 | cholesterol 25-hydroxylase; Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25- hydroxycholesterol by macrophages may play a role in Leydig cell differentiation | transmembrane protein 134 | 0.484 |
CH25H | TMEM183A | ENSP00000360918 | ENSP00000356211 | cholesterol 25-hydroxylase; Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25- hydroxycholesterol by macrophages may play a role in Leydig cell differentiation | transmembrane protein 183A | 0.442 |
FAM53A | TMEM183A | ENSP00000310057 | ENSP00000356211 | family with sequence similarity 53, member A; May play an important role in neural development; the dorsomedial roof of the third ventricle (By similarity) | transmembrane protein 183A | 0.504 |
IFIT3 | TMEM183A | ENSP00000360876 | ENSP00000356211 | interferon-induced protein with tetratricopeptide repeats 3; IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS- mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1 [...] | transmembrane protein 183A | 0.557 |
PIGQ | AP4S1 | ENSP00000026218 | ENSP00000216366 | phosphatidylinositol glycan anchor biosynthesis, class Q; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis | adaptor-related protein complex 4, sigma 1 subunit; Subunit of novel type of clathrin- or non-clathrin- associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system | 0.429 |
PIGQ | TMEM134 | ENSP00000026218 | ENSP00000312615 | phosphatidylinositol glycan anchor biosynthesis, class Q; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis | transmembrane protein 134 | 0.619 |
PIGQ | TMEM183A | ENSP00000026218 | ENSP00000356211 | phosphatidylinositol glycan anchor biosynthesis, class Q; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis | transmembrane protein 183A | 0.611 |
SNCA | TMEM183A | ENSP00000338345 | ENSP00000356211 | synuclein, alpha (non A4 component of amyloid precursor); May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation | transmembrane protein 183A | 0.513 |
SNCA | UBC | ENSP00000338345 | ENSP00000344818 | synuclein, alpha (non A4 component of amyloid precursor); May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation | ubiquitin C | 0.999 |
TMEM134 | AP4S1 | ENSP00000312615 | ENSP00000216366 | transmembrane protein 134 | adaptor-related protein complex 4, sigma 1 subunit; Subunit of novel type of clathrin- or non-clathrin- associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system | 0.546 |
TMEM134 | CH25H | ENSP00000312615 | ENSP00000360918 | transmembrane protein 134 | cholesterol 25-hydroxylase; Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25- hydroxycholesterol by macrophages may play a role in Leydig cell differentiation | 0.484 |
TMEM134 | PIGQ | ENSP00000312615 | ENSP00000026218 | transmembrane protein 134 | phosphatidylinositol glycan anchor biosynthesis, class Q; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis | 0.619 |
TMEM134 | TMEM183A | ENSP00000312615 | ENSP00000356211 | transmembrane protein 134 | transmembrane protein 183A | 0.687 |
TMEM134 | VIPAS39 | ENSP00000312615 | ENSP00000339122 | transmembrane protein 134 | VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog; May play a role in vesicular trafficking during spermatogenesis (By similarity). Plays a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes. May play a role in epithelial polarization through stabilization of apical membrane protein content, possibly via the RAB11A-dependent apical recycling pathway. Also involved in direct or indirect transcriptional regulation of E-cadherin | 0.604 |
TMEM134 | VPS33B | ENSP00000312615 | ENSP00000327650 | transmembrane protein 134 | vacuolar protein sorting 33 homolog B (yeast); May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Mediates phagolysosomal fusion in macrophages | 0.412 |
TMEM183A | AP4S1 | ENSP00000356211 | ENSP00000216366 | transmembrane protein 183A | adaptor-related protein complex 4, sigma 1 subunit; Subunit of novel type of clathrin- or non-clathrin- associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system | 0.532 |