| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMT | DHFR | ENSP00000273588 | ENSP00000396308 | aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity) | dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1 | 0.925 |
| AMT | FTCD | ENSP00000273588 | ENSP00000291670 | aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity) | formiminotransferase cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool | 0.913 |
| AMT | MTHFD1 | ENSP00000273588 | ENSP00000450560 | aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity) | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase | 0.981 |
| AMT | MTHFD1L | ENSP00000273588 | ENSP00000356290 | aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity) | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like; May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2 (By similarity) | 0.983 |
| AMT | MTHFD2 | ENSP00000273588 | ENSP00000377617 | aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity) | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.984 |
| AMT | MTR | ENSP00000273588 | ENSP00000355536 | aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity) | 5-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity) | 0.911 |
| AMT | PFAS | ENSP00000273588 | ENSP00000313490 | aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity) | phosphoribosylformylglycinamidine synthase | 0.491 |
| AMT | SHMT1 | ENSP00000273588 | ENSP00000318868 | aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity) | serine hydroxymethyltransferase 1 (soluble); Interconversion of serine and glycine (By similarity) | 0.985 |
| AMT | SHMT2 | ENSP00000273588 | ENSP00000333667 | aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity) | serine hydroxymethyltransferase 2 (mitochondrial); Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA | 0.988 |
| DHFR | AMT | ENSP00000396308 | ENSP00000273588 | dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1 | aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity) | 0.925 |
| DHFR | FTCD | ENSP00000396308 | ENSP00000291670 | dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1 | formiminotransferase cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool | 0.921 |
| DHFR | GART | ENSP00000396308 | ENSP00000371236 | dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1 | phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase | 0.528 |
| DHFR | MTHFD1 | ENSP00000396308 | ENSP00000450560 | dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase | 0.979 |
| DHFR | MTHFD1L | ENSP00000396308 | ENSP00000356290 | dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like; May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2 (By similarity) | 0.973 |
| DHFR | MTHFD2 | ENSP00000396308 | ENSP00000377617 | dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.438 |
| DHFR | MTR | ENSP00000396308 | ENSP00000355536 | dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1 | 5-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity) | 0.930 |
| DHFR | SHMT1 | ENSP00000396308 | ENSP00000318868 | dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1 | serine hydroxymethyltransferase 1 (soluble); Interconversion of serine and glycine (By similarity) | 0.995 |
| DHFR | SHMT2 | ENSP00000396308 | ENSP00000333667 | dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1 | serine hydroxymethyltransferase 2 (mitochondrial); Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA | 0.974 |
| FTCD | AMT | ENSP00000291670 | ENSP00000273588 | formiminotransferase cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool | aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity) | 0.913 |
| FTCD | DHFR | ENSP00000291670 | ENSP00000396308 | formiminotransferase cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool | dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1 | 0.921 |
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