node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MYB | PCMT1 | ENSP00000339992 | ENSP00000356348 | v-myb myeloblastosis viral oncogene homolog (avian) | protein-L-isoaspartate (D-aspartate) O-methyltransferase | 0.681 |
MYB | UBC | ENSP00000339992 | ENSP00000344818 | v-myb myeloblastosis viral oncogene homolog (avian) | ubiquitin C | 0.950 |
PCMT1 | MYB | ENSP00000356348 | ENSP00000339992 | protein-L-isoaspartate (D-aspartate) O-methyltransferase | v-myb myeloblastosis viral oncogene homolog (avian) | 0.681 |
PCMT1 | PFDN2 | ENSP00000356348 | ENSP00000356989 | protein-L-isoaspartate (D-aspartate) O-methyltransferase | prefoldin subunit 2; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins | 0.644 |
PCMT1 | PPIH | ENSP00000356348 | ENSP00000306614 | protein-L-isoaspartate (D-aspartate) O-methyltransferase | peptidylprolyl isomerase H (cyclophilin H); PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone | 0.695 |
PCMT1 | RAD23A | ENSP00000356348 | ENSP00000467024 | protein-L-isoaspartate (D-aspartate) O-methyltransferase | RAD23 homolog A (S. cerevisiae); Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to ’Lys-48’-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to ’Lys-63’-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome | 0.644 |
PCMT1 | RRM2 | ENSP00000356348 | ENSP00000353770 | protein-L-isoaspartate (D-aspartate) O-methyltransferase | ribonucleotide reductase M2; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling | 0.822 |
PCMT1 | SEC24A | ENSP00000356348 | ENSP00000381823 | protein-L-isoaspartate (D-aspartate) O-methyltransferase | SEC24 family, member A (S. cerevisiae); Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex | 0.644 |
PCMT1 | UBC | ENSP00000356348 | ENSP00000344818 | protein-L-isoaspartate (D-aspartate) O-methyltransferase | ubiquitin C | 0.923 |
PCMT1 | UBE2M | ENSP00000356348 | ENSP00000253023 | protein-L-isoaspartate (D-aspartate) O-methyltransferase | ubiquitin-conjugating enzyme E2M; Accepts the ubiquitin-like protein NEDD8 from the UBA3- NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation | 0.719 |
PCMT1 | UCHL3 | ENSP00000356348 | ENSP00000366819 | protein-L-isoaspartate (D-aspartate) O-methyltransferase | ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase); Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3", and exhibits a preference towards ’Lys-48’-linked Ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGF [...] | 0.644 |
PCMT1 | ZRANB2 | ENSP00000356348 | ENSP00000359958 | protein-L-isoaspartate (D-aspartate) O-methyltransferase | zinc finger, RAN-binding domain containing 2; Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5’- splice site selection | 0.644 |
PFDN2 | PCMT1 | ENSP00000356989 | ENSP00000356348 | prefoldin subunit 2; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins | protein-L-isoaspartate (D-aspartate) O-methyltransferase | 0.644 |
PFDN2 | UBC | ENSP00000356989 | ENSP00000344818 | prefoldin subunit 2; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins | ubiquitin C | 0.910 |
PPIH | PCMT1 | ENSP00000306614 | ENSP00000356348 | peptidylprolyl isomerase H (cyclophilin H); PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone | protein-L-isoaspartate (D-aspartate) O-methyltransferase | 0.695 |
PPIH | UBC | ENSP00000306614 | ENSP00000344818 | peptidylprolyl isomerase H (cyclophilin H); PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone | ubiquitin C | 0.946 |
RAD23A | PCMT1 | ENSP00000467024 | ENSP00000356348 | RAD23 homolog A (S. cerevisiae); Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to ’Lys-48’-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to ’Lys-63’-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome | protein-L-isoaspartate (D-aspartate) O-methyltransferase | 0.644 |
RAD23A | UBC | ENSP00000467024 | ENSP00000344818 | RAD23 homolog A (S. cerevisiae); Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to ’Lys-48’-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to ’Lys-63’-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome | ubiquitin C | 0.999 |
RAD23A | UCHL3 | ENSP00000467024 | ENSP00000366819 | RAD23 homolog A (S. cerevisiae); Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to ’Lys-48’-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to ’Lys-63’-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome | ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase); Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3", and exhibits a preference towards ’Lys-48’-linked Ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGF [...] | 0.727 |
RRM2 | PCMT1 | ENSP00000353770 | ENSP00000356348 | ribonucleotide reductase M2; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling | protein-L-isoaspartate (D-aspartate) O-methyltransferase | 0.822 |