node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BICD2 | NEK7 | ENSP00000349351 | ENSP00000356355 | bicaudal D homolog 2 (Drosophila); May play a role in the dynein-dynactin interactions on the surface of membranous organelles, by associating with these complexes. Regulates coat complex coatomer protein I (COPI)- independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex (By similarity) | NIMA-related kinase 7; Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1 | 0.758 |
BICD2 | NEK9 | ENSP00000349351 | ENSP00000238616 | bicaudal D homolog 2 (Drosophila); May play a role in the dynein-dynactin interactions on the surface of membranous organelles, by associating with these complexes. Regulates coat complex coatomer protein I (COPI)- independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex (By similarity) | NIMA-related kinase 9; Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively | 0.987 |
BICD2 | UBC | ENSP00000349351 | ENSP00000344818 | bicaudal D homolog 2 (Drosophila); May play a role in the dynein-dynactin interactions on the surface of membranous organelles, by associating with these complexes. Regulates coat complex coatomer protein I (COPI)- independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex (By similarity) | ubiquitin C | 0.515 |
CRB2 | DENND1A | ENSP00000362734 | ENSP00000362727 | crumbs homolog 2 (Drosophila); May play a role in polarized cells morphogenesis | DENN/MADD domain containing 1A | 0.669 |
CRB2 | DENND1B | ENSP00000362734 | ENSP00000356366 | crumbs homolog 2 (Drosophila); May play a role in polarized cells morphogenesis | DENN/MADD domain containing 1B | 0.564 |
CRB2 | LHX2 | ENSP00000362734 | ENSP00000362717 | crumbs homolog 2 (Drosophila); May play a role in polarized cells morphogenesis | LIM homeobox 2; Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity) | 0.775 |
CRB2 | LHX9 | ENSP00000362734 | ENSP00000356357 | crumbs homolog 2 (Drosophila); May play a role in polarized cells morphogenesis | LIM homeobox 9; Involved in gonadal development (By similarity) | 0.750 |
CRB2 | NEK7 | ENSP00000362734 | ENSP00000356355 | crumbs homolog 2 (Drosophila); May play a role in polarized cells morphogenesis | NIMA-related kinase 7; Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1 | 0.685 |
DENND1A | CRB2 | ENSP00000362727 | ENSP00000362734 | DENN/MADD domain containing 1A | crumbs homolog 2 (Drosophila); May play a role in polarized cells morphogenesis | 0.669 |
DENND1A | LHX2 | ENSP00000362727 | ENSP00000362717 | DENN/MADD domain containing 1A | LIM homeobox 2; Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity) | 0.606 |
DENND1A | LHX9 | ENSP00000362727 | ENSP00000356357 | DENN/MADD domain containing 1A | LIM homeobox 9; Involved in gonadal development (By similarity) | 0.563 |
DENND1A | NEK7 | ENSP00000362727 | ENSP00000356355 | DENN/MADD domain containing 1A | NIMA-related kinase 7; Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1 | 0.687 |
DENND1B | CRB2 | ENSP00000356366 | ENSP00000362734 | DENN/MADD domain containing 1B | crumbs homolog 2 (Drosophila); May play a role in polarized cells morphogenesis | 0.564 |
DENND1B | LHX2 | ENSP00000356366 | ENSP00000362717 | DENN/MADD domain containing 1B | LIM homeobox 2; Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity) | 0.485 |
DENND1B | LHX9 | ENSP00000356366 | ENSP00000356357 | DENN/MADD domain containing 1B | LIM homeobox 9; Involved in gonadal development (By similarity) | 0.487 |
DENND1B | NEK7 | ENSP00000356366 | ENSP00000356355 | DENN/MADD domain containing 1B | NIMA-related kinase 7; Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1 | 0.655 |
LHX2 | CRB2 | ENSP00000362717 | ENSP00000362734 | LIM homeobox 2; Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity) | crumbs homolog 2 (Drosophila); May play a role in polarized cells morphogenesis | 0.775 |
LHX2 | DENND1A | ENSP00000362717 | ENSP00000362727 | LIM homeobox 2; Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity) | DENN/MADD domain containing 1A | 0.606 |
LHX2 | DENND1B | ENSP00000362717 | ENSP00000356366 | LIM homeobox 2; Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity) | DENN/MADD domain containing 1B | 0.485 |
LHX2 | NEK7 | ENSP00000362717 | ENSP00000356355 | LIM homeobox 2; Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity) | NIMA-related kinase 7; Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1 | 0.610 |