node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GBX2 | LHX9 | ENSP00000302251 | ENSP00000356357 | gastrulation brain homeobox 2; May act as a transcription factor for cell pluripotency and differentiation in the embryo | LIM homeobox 9; Involved in gonadal development (By similarity) | 0.883 |
LDB1 | LHX9 | ENSP00000392466 | ENSP00000356357 | LIM domain binding 1; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Play a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (By similarity) | LIM homeobox 9; Involved in gonadal development (By similarity) | 0.836 |
LDB2 | LHX9 | ENSP00000306772 | ENSP00000356357 | LIM domain binding 2; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors | LIM homeobox 9; Involved in gonadal development (By similarity) | 0.981 |
LFNG | LHX9 | ENSP00000222725 | ENSP00000356357 | LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; Glycosyltransferase that initiates the elongation of O- linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Decreases the binding of JAGGED1 to NOTCH2 but not that of DELTA1. Essential mediator of somite segmentation and patterning (By similarity) | LIM homeobox 9; Involved in gonadal development (By similarity) | 0.920 |
LHX9 | GBX2 | ENSP00000356357 | ENSP00000302251 | LIM homeobox 9; Involved in gonadal development (By similarity) | gastrulation brain homeobox 2; May act as a transcription factor for cell pluripotency and differentiation in the embryo | 0.883 |
LHX9 | LDB1 | ENSP00000356357 | ENSP00000392466 | LIM homeobox 9; Involved in gonadal development (By similarity) | LIM domain binding 1; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Play a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (By similarity) | 0.836 |
LHX9 | LDB2 | ENSP00000356357 | ENSP00000306772 | LIM homeobox 9; Involved in gonadal development (By similarity) | LIM domain binding 2; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors | 0.981 |
LHX9 | LFNG | ENSP00000356357 | ENSP00000222725 | LIM homeobox 9; Involved in gonadal development (By similarity) | LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; Glycosyltransferase that initiates the elongation of O- linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Decreases the binding of JAGGED1 to NOTCH2 but not that of DELTA1. Essential mediator of somite segmentation and patterning (By similarity) | 0.920 |
LHX9 | MFNG | ENSP00000356357 | ENSP00000349490 | LIM homeobox 9; Involved in gonadal development (By similarity) | MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; Glycosyltransferase involved in the elongation of O- linked ligands to activate Notch signaling. Possesses fucose- specific beta-1,3-N-acetylglucosaminyltransferase activity | 0.919 |
LHX9 | MSX1 | ENSP00000356357 | ENSP00000372170 | LIM homeobox 9; Involved in gonadal development (By similarity) | msh homeobox 1; Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity | 0.802 |
LHX9 | MSX2 | ENSP00000356357 | ENSP00000239243 | LIM homeobox 9; Involved in gonadal development (By similarity) | msh homeobox 2; Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter | 0.795 |
LHX9 | NR5A1 | ENSP00000356357 | ENSP00000362690 | LIM homeobox 9; Involved in gonadal development (By similarity) | nuclear receptor subfamily 5, group A, member 1; Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5’-YCAAGGYC-3’ and 5’-RRAGGTCA-3’ are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO- NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional a [...] | 0.855 |
LHX9 | RFNG | ENSP00000356357 | ENSP00000307971 | LIM homeobox 9; Involved in gonadal development (By similarity) | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; Glycosyltransferase that initiates the elongation of O- linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. May be involved in limb formation and in neurogenesis (By similarity) | 0.919 |
LHX9 | VSX2 | ENSP00000356357 | ENSP00000261980 | LIM homeobox 9; Involved in gonadal development (By similarity) | visual system homeobox 2; Plays a significant role in the specification and morphogenesis of the sensory retina. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells (By similarity) | 0.777 |
MFNG | LHX9 | ENSP00000349490 | ENSP00000356357 | MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; Glycosyltransferase involved in the elongation of O- linked ligands to activate Notch signaling. Possesses fucose- specific beta-1,3-N-acetylglucosaminyltransferase activity | LIM homeobox 9; Involved in gonadal development (By similarity) | 0.919 |
MSX1 | LHX9 | ENSP00000372170 | ENSP00000356357 | msh homeobox 1; Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity | LIM homeobox 9; Involved in gonadal development (By similarity) | 0.802 |
MSX1 | MSX2 | ENSP00000372170 | ENSP00000239243 | msh homeobox 1; Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity | msh homeobox 2; Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter | 0.592 |
MSX2 | LHX9 | ENSP00000239243 | ENSP00000356357 | msh homeobox 2; Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter | LIM homeobox 9; Involved in gonadal development (By similarity) | 0.795 |
MSX2 | MSX1 | ENSP00000239243 | ENSP00000372170 | msh homeobox 2; Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter | msh homeobox 1; Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity | 0.592 |
NR5A1 | LHX9 | ENSP00000362690 | ENSP00000356357 | nuclear receptor subfamily 5, group A, member 1; Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5’-YCAAGGYC-3’ and 5’-RRAGGTCA-3’ are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO- NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional a [...] | LIM homeobox 9; Involved in gonadal development (By similarity) | 0.855 |