node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASPM | CDK5RAP2 | ENSP00000356379 | ENSP00000343818 | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | CDK5 regulatory subunit associated protein 2 | 0.779 |
ASPM | CENPJ | ENSP00000356379 | ENSP00000371308 | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | centromere protein J; Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome | 0.770 |
ASPM | CEP152 | ENSP00000356379 | ENSP00000382271 | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | centrosomal protein 152kDa; Regulator of genomic integrity and cellular response to DNA damage acting through ATR-mediated checkpoint signaling. Necessary for centrosome duplication. It functions as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, two molecules involved in centriole formation | 0.761 |
ASPM | CEP63 | ENSP00000356379 | ENSP00000336524 | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | centrosomal protein 63kDa; Required for normal spindle assembly. Maintains centrosome numbers through centrosomal recruitment of CEP152. Also recruits CDK1 to centrosomes. Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (By similarity) | 0.822 |
ASPM | CIT | ENSP00000356379 | ENSP00000376306 | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | citron (rho-interacting, serine/threonine kinase 21); Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2 | 0.777 |
ASPM | KIF11 | ENSP00000356379 | ENSP00000260731 | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | kinesin family member 11; Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays | 0.823 |
ASPM | MCPH1 | ENSP00000356379 | ENSP00000342924 | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | microcephalin 1; Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex | 0.835 |
ASPM | PLK1 | ENSP00000356379 | ENSP00000300093 | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | polo-like kinase 1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55 [...] | 0.771 |
ASPM | STIL | ENSP00000356379 | ENSP00000360944 | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | SCL/TAL1 interrupting locus; Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1 | 0.759 |
ASPM | UBC | ENSP00000356379 | ENSP00000344818 | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | ubiquitin C | 0.921 |
CDK5RAP2 | ASPM | ENSP00000343818 | ENSP00000356379 | CDK5 regulatory subunit associated protein 2 | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.779 |
CDK5RAP2 | CENPJ | ENSP00000343818 | ENSP00000371308 | CDK5 regulatory subunit associated protein 2 | centromere protein J; Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome | 0.982 |
CDK5RAP2 | CEP152 | ENSP00000343818 | ENSP00000382271 | CDK5 regulatory subunit associated protein 2 | centrosomal protein 152kDa; Regulator of genomic integrity and cellular response to DNA damage acting through ATR-mediated checkpoint signaling. Necessary for centrosome duplication. It functions as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, two molecules involved in centriole formation | 0.976 |
CDK5RAP2 | CEP63 | ENSP00000343818 | ENSP00000336524 | CDK5 regulatory subunit associated protein 2 | centrosomal protein 63kDa; Required for normal spindle assembly. Maintains centrosome numbers through centrosomal recruitment of CEP152. Also recruits CDK1 to centrosomes. Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (By similarity) | 0.973 |
CDK5RAP2 | MCPH1 | ENSP00000343818 | ENSP00000342924 | CDK5 regulatory subunit associated protein 2 | microcephalin 1; Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex | 0.770 |
CDK5RAP2 | PLK1 | ENSP00000343818 | ENSP00000300093 | CDK5 regulatory subunit associated protein 2 | polo-like kinase 1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55 [...] | 0.966 |
CDK5RAP2 | STIL | ENSP00000343818 | ENSP00000360944 | CDK5 regulatory subunit associated protein 2 | SCL/TAL1 interrupting locus; Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1 | 0.749 |
CDK5RAP2 | UBC | ENSP00000343818 | ENSP00000344818 | CDK5 regulatory subunit associated protein 2 | ubiquitin C | 0.849 |
CENPJ | ASPM | ENSP00000371308 | ENSP00000356379 | centromere protein J; Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.770 |
CENPJ | CDK5RAP2 | ENSP00000371308 | ENSP00000343818 | centromere protein J; Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome | CDK5 regulatory subunit associated protein 2 | 0.982 |