| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARMS2 | C3 | ENSP00000436682 | ENSP00000245907 | age-related maculopathy susceptibility 2 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | 0.468 |
| ARMS2 | CFHR4 | ENSP00000436682 | ENSP00000356386 | age-related maculopathy susceptibility 2 | complement factor H-related 4; Involved in complement regulation. Can associate with lipoproteins and may play a role in lipid metabolism | 0.414 |
| C3 | ARMS2 | ENSP00000245907 | ENSP00000436682 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | age-related maculopathy susceptibility 2 | 0.468 |
| C3 | CD46 | ENSP00000245907 | ENSP00000313875 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | CD46 molecule, complement regulatory protein | 0.998 |
| C3 | CFHR4 | ENSP00000245907 | ENSP00000356386 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | complement factor H-related 4; Involved in complement regulation. Can associate with lipoproteins and may play a role in lipid metabolism | 0.966 |
| C3 | RBMS1 | ENSP00000245907 | ENSP00000294904 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | RNA binding motif, single stranded interacting protein 1; Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds specifically to the DNA sequence motif 5’-[AT]CT[AT][AT]T-3’. Probably has a role in DNA replication | 0.591 |
| C3 | RBMS2 | ENSP00000245907 | ENSP00000262031 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | RNA binding motif, single stranded interacting protein 2 | 0.639 |
| C4BPB | CFHR4 | ENSP00000243611 | ENSP00000356386 | complement component 4 binding protein, beta; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S | complement factor H-related 4; Involved in complement regulation. Can associate with lipoproteins and may play a role in lipid metabolism | 0.510 |
| C4BPB | CNDP2 | ENSP00000243611 | ENSP00000325548 | complement component 4 binding protein, beta; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S | CNDP dipeptidase 2 (metallopeptidase M20 family); Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Isoform 2 may be play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells | 0.514 |
| CD46 | C3 | ENSP00000313875 | ENSP00000245907 | CD46 molecule, complement regulatory protein | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | 0.998 |
| CD46 | CFHR4 | ENSP00000313875 | ENSP00000356386 | CD46 molecule, complement regulatory protein | complement factor H-related 4; Involved in complement regulation. Can associate with lipoproteins and may play a role in lipid metabolism | 0.510 |
| CD46 | RBMS1 | ENSP00000313875 | ENSP00000294904 | CD46 molecule, complement regulatory protein | RNA binding motif, single stranded interacting protein 1; Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds specifically to the DNA sequence motif 5’-[AT]CT[AT][AT]T-3’. Probably has a role in DNA replication | 0.459 |
| CFHR4 | ARMS2 | ENSP00000356386 | ENSP00000436682 | complement factor H-related 4; Involved in complement regulation. Can associate with lipoproteins and may play a role in lipid metabolism | age-related maculopathy susceptibility 2 | 0.414 |
| CFHR4 | C3 | ENSP00000356386 | ENSP00000245907 | complement factor H-related 4; Involved in complement regulation. Can associate with lipoproteins and may play a role in lipid metabolism | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | 0.966 |
| CFHR4 | C4BPB | ENSP00000356386 | ENSP00000243611 | complement factor H-related 4; Involved in complement regulation. Can associate with lipoproteins and may play a role in lipid metabolism | complement component 4 binding protein, beta; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S | 0.510 |
| CFHR4 | CD46 | ENSP00000356386 | ENSP00000313875 | complement factor H-related 4; Involved in complement regulation. Can associate with lipoproteins and may play a role in lipid metabolism | CD46 molecule, complement regulatory protein | 0.510 |
| CFHR4 | CNDP2 | ENSP00000356386 | ENSP00000325548 | complement factor H-related 4; Involved in complement regulation. Can associate with lipoproteins and may play a role in lipid metabolism | CNDP dipeptidase 2 (metallopeptidase M20 family); Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Isoform 2 may be play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells | 0.519 |
| CFHR4 | RBMS1 | ENSP00000356386 | ENSP00000294904 | complement factor H-related 4; Involved in complement regulation. Can associate with lipoproteins and may play a role in lipid metabolism | RNA binding motif, single stranded interacting protein 1; Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds specifically to the DNA sequence motif 5’-[AT]CT[AT][AT]T-3’. Probably has a role in DNA replication | 0.414 |
| CFHR4 | RBMS2 | ENSP00000356386 | ENSP00000262031 | complement factor H-related 4; Involved in complement regulation. Can associate with lipoproteins and may play a role in lipid metabolism | RNA binding motif, single stranded interacting protein 2 | 0.499 |
| CNDP2 | C4BPB | ENSP00000325548 | ENSP00000243611 | CNDP dipeptidase 2 (metallopeptidase M20 family); Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Isoform 2 may be play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells | complement component 4 binding protein, beta; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S | 0.514 |
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