node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARMS2 | C3 | ENSP00000436682 | ENSP00000245907 | age-related maculopathy susceptibility 2 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | 0.468 |
ARMS2 | CFB | ENSP00000436682 | ENSP00000416561 | age-related maculopathy susceptibility 2 | complement factor B | 0.723 |
ARMS2 | CFHR3 | ENSP00000436682 | ENSP00000356395 | age-related maculopathy susceptibility 2 | complement factor H-related 3; Might be involved in complement regulation | 0.720 |
ARMS2 | HMCN1 | ENSP00000436682 | ENSP00000271588 | age-related maculopathy susceptibility 2 | hemicentin 1 | 0.938 |
ARMS2 | HTRA1 | ENSP00000436682 | ENSP00000357980 | age-related maculopathy susceptibility 2 | HtrA serine peptidase 1; Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits sig [...] | 0.880 |
C3 | ARMS2 | ENSP00000245907 | ENSP00000436682 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | age-related maculopathy susceptibility 2 | 0.468 |
C3 | C4BPA | ENSP00000245907 | ENSP00000356037 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | complement component 4 binding protein, alpha; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component | 0.680 |
C3 | CD46 | ENSP00000245907 | ENSP00000313875 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | CD46 molecule, complement regulatory protein | 0.998 |
C3 | CFB | ENSP00000245907 | ENSP00000416561 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | complement factor B | 0.990 |
C3 | CFHR3 | ENSP00000245907 | ENSP00000356395 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | complement factor H-related 3; Might be involved in complement regulation | 0.970 |
C3 | CFI | ENSP00000245907 | ENSP00000378130 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | complement factor I; Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively | 0.997 |
C3 | HMCN1 | ENSP00000245907 | ENSP00000271588 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | hemicentin 1 | 0.410 |
C3 | RBMS2 | ENSP00000245907 | ENSP00000262031 | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | RNA binding motif, single stranded interacting protein 2 | 0.639 |
C4BPA | C3 | ENSP00000356037 | ENSP00000245907 | complement component 4 binding protein, alpha; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | 0.680 |
C4BPA | CFHR3 | ENSP00000356037 | ENSP00000356395 | complement component 4 binding protein, alpha; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component | complement factor H-related 3; Might be involved in complement regulation | 0.493 |
C4BPA | CFI | ENSP00000356037 | ENSP00000378130 | complement component 4 binding protein, alpha; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component | complement factor I; Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively | 0.923 |
CD46 | C3 | ENSP00000313875 | ENSP00000245907 | CD46 molecule, complement regulatory protein | complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates | 0.998 |
CD46 | CFHR3 | ENSP00000313875 | ENSP00000356395 | CD46 molecule, complement regulatory protein | complement factor H-related 3; Might be involved in complement regulation | 0.584 |
CD46 | CFI | ENSP00000313875 | ENSP00000378130 | CD46 molecule, complement regulatory protein | complement factor I; Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively | 0.949 |
CFB | ARMS2 | ENSP00000416561 | ENSP00000436682 | complement factor B | age-related maculopathy susceptibility 2 | 0.723 |