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HMCN1 HMCN1 ARMS2 ARMS2 GOLGA6L9 GOLGA6L9 HTRA1 HTRA1 CFHR3 CFHR3 CFB CFB C3 C3 RBMS2 RBMS2 CD46 CD46 CFI CFI C4BPA C4BPA
"CFHR3" - complement factor H-related 3 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
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Textmining
[Homology]
Score
CFHR3complement factor H-related 3; Might be involved in complement regulation (330 aa)    
Predicted Functional Partners:
C3
complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates (1663 aa)
        score_image   score_image   0.970
ARMS2
age-related maculopathy susceptibility 2 (107 aa)
            score_image   0.720
HMCN1
hemicentin 1 (5635 aa)
            score_image   0.669
RBMS2
RNA binding motif, single stranded interacting protein 2 (407 aa)
            score_image   0.658
CD46
CD46 molecule, complement regulatory protein (399 aa)
            score_image   0.584
CFB
complement factor B (764 aa)
            score_image   0.569
HTRA1
HtrA serine peptidase 1; Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits sig [...] (480 aa)
            score_image   0.508
C4BPA
complement component 4 binding protein, alpha; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component (597 aa)
            score_image   0.493
GOLGA6L9
golgin A6 family-like 9 (432 aa)
            score_image   0.471
CFI
complement factor I; Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively (583 aa)
            score_image   0.459
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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