node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
B3GALT2 | FAM5C | ENSP00000356404 | ENSP00000356432 | UDP-Gal-betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2; Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N- acetylglucosamine (beta-GlcNAc) residue. Can also utilize substrates with a terminal galactose residue, albeit with lower efficiency. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Inactive towards substrates with terminal alpha-N-acetylglucosamine (alpha-GlcNAc) or alpha-N-acetylgalactosamine (alpha-GalNAc) residues | family with sequence similarity 5, member C | 0.582 |
B3GALT2 | TROVE2 | ENSP00000356404 | ENSP00000356411 | UDP-Gal-betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2; Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N- acetylglucosamine (beta-GlcNAc) residue. Can also utilize substrates with a terminal galactose residue, albeit with lower efficiency. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Inactive towards substrates with terminal alpha-N-acetylglucosamine (alpha-GlcNAc) or alpha-N-acetylgalactosamine (alpha-GalNAc) residues | TROVE domain family, member 2; RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs. May stabilize some of these RNAs and protect them from degradation | 0.618 |
ENSG00000250151 | FAM5C | ENSP00000380427 | ENSP00000356432 | ARPC4-TTLL3 readthrough; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament | family with sequence similarity 5, member C | 0.607 |
ENSG00000250151 | MON1B | ENSP00000380427 | ENSP00000248248 | ARPC4-TTLL3 readthrough; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament | MON1 homolog B (yeast) | 0.607 |
ENSG00000250151 | TBC1D24 | ENSP00000380427 | ENSP00000293970 | ARPC4-TTLL3 readthrough; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament | TBC1 domain family, member 24; May act as a GTPase-activating protein for Rab family protein(s). Involved in neuronal projections development, probably through a negative modulation of ARF6 function | 0.528 |
FAM5C | B3GALT2 | ENSP00000356432 | ENSP00000356404 | family with sequence similarity 5, member C | UDP-Gal-betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2; Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N- acetylglucosamine (beta-GlcNAc) residue. Can also utilize substrates with a terminal galactose residue, albeit with lower efficiency. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Inactive towards substrates with terminal alpha-N-acetylglucosamine (alpha-GlcNAc) or alpha-N-acetylgalactosamine (alpha-GalNAc) residues | 0.582 |
FAM5C | ENSG00000250151 | ENSP00000356432 | ENSP00000380427 | family with sequence similarity 5, member C | ARPC4-TTLL3 readthrough; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament | 0.607 |
FAM5C | HSD17B6 | ENSP00000356432 | ENSP00000318631 | family with sequence similarity 5, member C | hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse); NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3- alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is firs [...] | 0.493 |
FAM5C | KIAA1244 | ENSP00000356432 | ENSP00000251691 | family with sequence similarity 5, member C | KIAA1244 | 0.501 |
FAM5C | MON1B | ENSP00000356432 | ENSP00000248248 | family with sequence similarity 5, member C | MON1 homolog B (yeast) | 0.659 |
FAM5C | OBFC1 | ENSP00000356432 | ENSP00000224950 | family with sequence similarity 5, member C | oligonucleotide/oligosaccharide-binding fold containing 1; Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites | 0.546 |
FAM5C | OR52E4 | ENSP00000356432 | ENSP00000321426 | family with sequence similarity 5, member C | olfactory receptor, family 52, subfamily E, member 4; Odorant receptor (Potential) | 0.649 |
FAM5C | TBC1D24 | ENSP00000356432 | ENSP00000293970 | family with sequence similarity 5, member C | TBC1 domain family, member 24; May act as a GTPase-activating protein for Rab family protein(s). Involved in neuronal projections development, probably through a negative modulation of ARF6 function | 0.648 |
FAM5C | TROVE2 | ENSP00000356432 | ENSP00000356411 | family with sequence similarity 5, member C | TROVE domain family, member 2; RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs. May stabilize some of these RNAs and protect them from degradation | 0.508 |
FAM5C | TTLL3 | ENSP00000356432 | ENSP00000392549 | family with sequence similarity 5, member C | tubulin tyrosine ligase-like family, member 3; Monoglycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction | 0.663 |
HSD17B6 | FAM5C | ENSP00000318631 | ENSP00000356432 | hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse); NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3- alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is firs [...] | family with sequence similarity 5, member C | 0.493 |
HSD17B6 | MON1B | ENSP00000318631 | ENSP00000248248 | hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse); NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3- alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is firs [...] | MON1 homolog B (yeast) | 0.505 |
HSD17B6 | TBC1D24 | ENSP00000318631 | ENSP00000293970 | hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse); NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3- alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is firs [...] | TBC1 domain family, member 24; May act as a GTPase-activating protein for Rab family protein(s). Involved in neuronal projections development, probably through a negative modulation of ARF6 function | 0.476 |
KIAA1244 | FAM5C | ENSP00000251691 | ENSP00000356432 | KIAA1244 | family with sequence similarity 5, member C | 0.501 |
MON1B | ENSG00000250151 | ENSP00000248248 | ENSP00000380427 | MON1 homolog B (yeast) | ARPC4-TTLL3 readthrough; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament | 0.607 |