SHCBP1L protein (Homo sapiens) - STRING network view

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SHCBP1L

SHC SH2-domain binding protein 1-like (653 aa)

Predicted Functional Partners:

SF3B2

0.599

GK5

0.583

NALCN

0.541

KLC3

0.522

FAM71D

0.517

SEC24C

0.516

ALLC

0.489

SEC24D

0.487

PDCD2L

0.420

HSPA2

0.405

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALLC	GK5	ENSP00000252505	ENSP00000418001	allantoicase; The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals	glycerol kinase 5 (putative)	0.454
ALLC	SHCBP1L	ENSP00000252505	ENSP00000356518	allantoicase; The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals	SHC SH2-domain binding protein 1-like	0.489
FAM71D	SF3B2	ENSP00000431905	ENSP00000318861	family with sequence similarity 71, member D	splicing factor 3b, subunit 2, 145kDa; Subunit of the splicing factor SF3B required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron	0.459
FAM71D	SHCBP1L	ENSP00000431905	ENSP00000356518	family with sequence similarity 71, member D	SHC SH2-domain binding protein 1-like	0.517
GK5	ALLC	ENSP00000418001	ENSP00000252505	glycerol kinase 5 (putative)	allantoicase; The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals	0.454
GK5	NALCN	ENSP00000418001	ENSP00000251127	glycerol kinase 5 (putative)	sodium leak channel, non-selective; Voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions. Responsible for the background sodium ion leak current in neurons and controls neuronal excitability. Activated either by neuropeptides substance P or neurotensin. Required for normal respiratory rhythm and neonatal survival (By similarity)	0.686
GK5	SHCBP1L	ENSP00000418001	ENSP00000356518	glycerol kinase 5 (putative)	SHC SH2-domain binding protein 1-like	0.583
HSPA2	SHCBP1L	ENSP00000247207	ENSP00000356518	heat shock 70kDa protein 2; In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage	SHC SH2-domain binding protein 1-like	0.405
KLC3	SHCBP1L	ENSP00000375810	ENSP00000356518	kinesin light chain 3; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport	SHC SH2-domain binding protein 1-like	0.522
NALCN	GK5	ENSP00000251127	ENSP00000418001	sodium leak channel, non-selective; Voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions. Responsible for the background sodium ion leak current in neurons and controls neuronal excitability. Activated either by neuropeptides substance P or neurotensin. Required for normal respiratory rhythm and neonatal survival (By similarity)	glycerol kinase 5 (putative)	0.686
NALCN	SHCBP1L	ENSP00000251127	ENSP00000356518	sodium leak channel, non-selective; Voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions. Responsible for the background sodium ion leak current in neurons and controls neuronal excitability. Activated either by neuropeptides substance P or neurotensin. Required for normal respiratory rhythm and neonatal survival (By similarity)	SHC SH2-domain binding protein 1-like	0.541
PDCD2L	SHCBP1L	ENSP00000246535	ENSP00000356518	programmed cell death 2-like; Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase	SHC SH2-domain binding protein 1-like	0.420
SEC24C	SEC24D	ENSP00000321845	ENSP00000280551	SEC24 family, member C (S. cerevisiae); Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex	SEC24 family, member D (S. cerevisiae); Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex	0.996
SEC24C	SHCBP1L	ENSP00000321845	ENSP00000356518	SEC24 family, member C (S. cerevisiae); Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex	SHC SH2-domain binding protein 1-like	0.516
SEC24D	SEC24C	ENSP00000280551	ENSP00000321845	SEC24 family, member D (S. cerevisiae); Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex	SEC24 family, member C (S. cerevisiae); Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex	0.996
SEC24D	SHCBP1L	ENSP00000280551	ENSP00000356518	SEC24 family, member D (S. cerevisiae); Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex	SHC SH2-domain binding protein 1-like	0.487
SF3B2	FAM71D	ENSP00000318861	ENSP00000431905	splicing factor 3b, subunit 2, 145kDa; Subunit of the splicing factor SF3B required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron	family with sequence similarity 71, member D	0.459
SF3B2	SHCBP1L	ENSP00000318861	ENSP00000356518	splicing factor 3b, subunit 2, 145kDa; Subunit of the splicing factor SF3B required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron	SHC SH2-domain binding protein 1-like	0.599
SHCBP1L	ALLC	ENSP00000356518	ENSP00000252505	SHC SH2-domain binding protein 1-like	allantoicase; The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals	0.489
SHCBP1L	FAM71D	ENSP00000356518	ENSP00000431905	SHC SH2-domain binding protein 1-like	family with sequence similarity 71, member D	0.517

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