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H326 H326 PEX12 PEX12 PEX16 PEX16 PEX13 PEX13 PEX14 PEX14 ABCD3 ABCD3 PEX26 PEX26 PEX19 PEX19 PEX3 PEX3 UBC UBC HNRNPF HNRNPF
"PEX3" - peroxisomal biogenesis factor 3 in Homo sapiens
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PEX3peroxisomal biogenesis factor 3; Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes (373 aa)    
Predicted Functional Partners:
PEX19
peroxisomal biogenesis factor 19; Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53 (299 aa)
      score_image score_image   score_image   0.999
PEX13
peroxisomal biogenesis factor 13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins (403 aa)
      score_image score_image   score_image   0.983
H326
DDB1- and CUL4-associated factor 8 ; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (751 aa)
      score_image score_image   score_image   0.980
UBC
ubiquitin C (685 aa)
        score_image       0.970
PEX12
peroxisomal biogenesis factor 12; Required for protein import into peroxisomes (359 aa)
      score_image score_image   score_image   0.966
ABCD3
ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity (659 aa)
      score_image score_image   score_image   0.956
PEX16
peroxisomal biogenesis factor 16; Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3 (346 aa)
        score_image   score_image   0.951
PEX14
peroxisomal biogenesis factor 14; Component of the peroxisomal translocation machinery with PEX13 and PEX17. Interacts with both the PTS1 and PTS2 receptors. Binds directly to PEX17 (377 aa)
      score_image score_image   score_image   0.939
HNRNPF
heterogeneous nuclear ribonucleoprotein F; Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state (415 aa)
        score_image       0.908
PEX26
peroxisomal biogenesis factor 26; Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence (305 aa)
        score_image   score_image   0.895
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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