node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCD3 | H326 | ENSP00000359233 | ENSP00000451235 | ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | DDB1- and CUL4-associated factor 8 ; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex | 0.820 |
ABCD3 | PEX12 | ENSP00000359233 | ENSP00000225873 | ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | peroxisomal biogenesis factor 12; Required for protein import into peroxisomes | 0.560 |
ABCD3 | PEX13 | ENSP00000359233 | ENSP00000295030 | ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | peroxisomal biogenesis factor 13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins | 0.779 |
ABCD3 | PEX14 | ENSP00000359233 | ENSP00000349016 | ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | peroxisomal biogenesis factor 14; Component of the peroxisomal translocation machinery with PEX13 and PEX17. Interacts with both the PTS1 and PTS2 receptors. Binds directly to PEX17 | 0.922 |
ABCD3 | PEX16 | ENSP00000359233 | ENSP00000241041 | ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | peroxisomal biogenesis factor 16; Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3 | 0.741 |
ABCD3 | PEX19 | ENSP00000359233 | ENSP00000357051 | ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | peroxisomal biogenesis factor 19; Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53 | 0.999 |
ABCD3 | PEX26 | ENSP00000359233 | ENSP00000331106 | ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | peroxisomal biogenesis factor 26; Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence | 0.545 |
ABCD3 | PEX3 | ENSP00000359233 | ENSP00000356563 | ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | peroxisomal biogenesis factor 3; Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes | 0.956 |
ABCD3 | UBC | ENSP00000359233 | ENSP00000344818 | ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | ubiquitin C | 0.942 |
H326 | ABCD3 | ENSP00000451235 | ENSP00000359233 | DDB1- and CUL4-associated factor 8 ; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex | ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | 0.820 |
H326 | PEX12 | ENSP00000451235 | ENSP00000225873 | DDB1- and CUL4-associated factor 8 ; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex | peroxisomal biogenesis factor 12; Required for protein import into peroxisomes | 0.978 |
H326 | PEX13 | ENSP00000451235 | ENSP00000295030 | DDB1- and CUL4-associated factor 8 ; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex | peroxisomal biogenesis factor 13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins | 0.978 |
H326 | PEX14 | ENSP00000451235 | ENSP00000349016 | DDB1- and CUL4-associated factor 8 ; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex | peroxisomal biogenesis factor 14; Component of the peroxisomal translocation machinery with PEX13 and PEX17. Interacts with both the PTS1 and PTS2 receptors. Binds directly to PEX17 | 0.975 |
H326 | PEX16 | ENSP00000451235 | ENSP00000241041 | DDB1- and CUL4-associated factor 8 ; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex | peroxisomal biogenesis factor 16; Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3 | 0.863 |
H326 | PEX26 | ENSP00000451235 | ENSP00000331106 | DDB1- and CUL4-associated factor 8 ; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex | peroxisomal biogenesis factor 26; Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence | 0.836 |
H326 | PEX3 | ENSP00000451235 | ENSP00000356563 | DDB1- and CUL4-associated factor 8 ; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex | peroxisomal biogenesis factor 3; Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes | 0.980 |
HNRNPF | PEX3 | ENSP00000338477 | ENSP00000356563 | heterogeneous nuclear ribonucleoprotein F; Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state | peroxisomal biogenesis factor 3; Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes | 0.908 |
HNRNPF | UBC | ENSP00000338477 | ENSP00000344818 | heterogeneous nuclear ribonucleoprotein F; Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state | ubiquitin C | 0.993 |
PEX12 | ABCD3 | ENSP00000225873 | ENSP00000359233 | peroxisomal biogenesis factor 12; Required for protein import into peroxisomes | ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | 0.560 |
PEX12 | H326 | ENSP00000225873 | ENSP00000451235 | peroxisomal biogenesis factor 12; Required for protein import into peroxisomes | DDB1- and CUL4-associated factor 8 ; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex | 0.978 |