GPR126 protein (Homo sapiens) - STRING network view

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Score

GPR126

G protein-coupled receptor 126 (1250 aa)

Predicted Functional Partners:

EGR2

0.883

SELL

0.813

NPPC

0.681

SBF2

0.681

LIN28B

0.680

MCM6

0.610

FLNB

0.590

NAALADL1

0.585

SELE

0.572

HECA

0.563

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGR2	GPR126	ENSP00000242480	ENSP00000356581	early growth response 2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4	G protein-coupled receptor 126	0.883
EGR2	SBF2	ENSP00000242480	ENSP00000256190	early growth response 2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4	SET binding factor 2	0.504
FLNB	GPR126	ENSP00000420213	ENSP00000356581	filamin B, beta	G protein-coupled receptor 126	0.590
FLNB	LIN28B	ENSP00000420213	ENSP00000344401	filamin B, beta	lin-28 homolog B (C. elegans); Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre- let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5’-GGAG-3’ motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5’-GGAG-3’ motif in the terminal loop, leading to their terminal uridylation [...]	0.493
FLNB	MCM6	ENSP00000420213	ENSP00000264156	filamin B, beta	minichromosome maintenance complex component 6; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for ’once per cell cycle’ DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute dif [...]	0.440
FLNB	NPPC	ENSP00000420213	ENSP00000295440	filamin B, beta	natriuretic peptide C; Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity)	0.497
FLNB	SBF2	ENSP00000420213	ENSP00000256190	filamin B, beta	SET binding factor 2	0.516
GPR126	EGR2	ENSP00000356581	ENSP00000242480	G protein-coupled receptor 126	early growth response 2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4	0.883
GPR126	FLNB	ENSP00000356581	ENSP00000420213	G protein-coupled receptor 126	filamin B, beta	0.590
GPR126	HECA	ENSP00000356581	ENSP00000356630	G protein-coupled receptor 126	headcase homolog (Drosophila); May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs	0.563
GPR126	LIN28B	ENSP00000356581	ENSP00000344401	G protein-coupled receptor 126	lin-28 homolog B (C. elegans); Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre- let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5’-GGAG-3’ motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5’-GGAG-3’ motif in the terminal loop, leading to their terminal uridylation [...]	0.680
GPR126	MCM6	ENSP00000356581	ENSP00000264156	G protein-coupled receptor 126	minichromosome maintenance complex component 6; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for ’once per cell cycle’ DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute dif [...]	0.610
GPR126	NAALADL1	ENSP00000356581	ENSP00000351484	G protein-coupled receptor 126	N-acetylated alpha-linked acidic dipeptidase-like 1; NAALADase-like activity unknown. Has no NAAG hydrolyzing activity. Exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC (By similarity)	0.585
GPR126	NPPC	ENSP00000356581	ENSP00000295440	G protein-coupled receptor 126	natriuretic peptide C; Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity)	0.681
GPR126	SBF2	ENSP00000356581	ENSP00000256190	G protein-coupled receptor 126	SET binding factor 2	0.681
GPR126	SELE	ENSP00000356581	ENSP00000331736	G protein-coupled receptor 126	selectin E; Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis	0.572
GPR126	SELL	ENSP00000356581	ENSP00000236147	G protein-coupled receptor 126	selectin L; Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (By similarity)	0.813
HECA	GPR126	ENSP00000356630	ENSP00000356581	headcase homolog (Drosophila); May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs	G protein-coupled receptor 126	0.563
HECA	SELE	ENSP00000356630	ENSP00000331736	headcase homolog (Drosophila); May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs	selectin E; Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis	0.627
HECA	SELL	ENSP00000356630	ENSP00000236147	headcase homolog (Drosophila); May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs	selectin L; Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (By similarity)	0.671

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