node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C6orf52 | TOR1AIP2 | ENSP00000259983 | ENSP00000356584 | chromosome 6 open reading frame 52 | torsin A interacting protein 2; Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope | 0.567 |
COPS5 | COPS6 | ENSP00000350512 | ENSP00000304102 | COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis); Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via i [...] | COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis); Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...] | 0.999 |
COPS5 | TOR1AIP2 | ENSP00000350512 | ENSP00000356584 | COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis); Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via i [...] | torsin A interacting protein 2; Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope | 0.895 |
COPS5 | UBC | ENSP00000350512 | ENSP00000344818 | COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis); Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via i [...] | ubiquitin C | 0.995 |
COPS6 | COPS5 | ENSP00000304102 | ENSP00000350512 | COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis); Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...] | COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis); Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via i [...] | 0.999 |
COPS6 | TOR1AIP2 | ENSP00000304102 | ENSP00000356584 | COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis); Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...] | torsin A interacting protein 2; Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope | 0.930 |
COPS6 | UBC | ENSP00000304102 | ENSP00000344818 | COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis); Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...] | ubiquitin C | 0.973 |
ERLIN2 | KIAA1161 | ENSP00000276461 | ENSP00000297625 | ER lipid raft associated 2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway | KIAA1161; Putative glucosidase (By similarity) | 0.561 |
ERLIN2 | PPAPDC3 | ENSP00000276461 | ENSP00000361338 | ER lipid raft associated 2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway | phosphatidic acid phosphatase type 2 domain containing 3; Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity (By similarity) | 0.517 |
ERLIN2 | TOR1AIP2 | ENSP00000276461 | ENSP00000356584 | ER lipid raft associated 2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway | torsin A interacting protein 2; Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope | 0.620 |
ERLIN2 | UBC | ENSP00000276461 | ENSP00000344818 | ER lipid raft associated 2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway | ubiquitin C | 0.919 |
KIAA1161 | ERLIN2 | ENSP00000297625 | ENSP00000276461 | KIAA1161; Putative glucosidase (By similarity) | ER lipid raft associated 2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway | 0.561 |
KIAA1161 | PPAPDC3 | ENSP00000297625 | ENSP00000361338 | KIAA1161; Putative glucosidase (By similarity) | phosphatidic acid phosphatase type 2 domain containing 3; Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity (By similarity) | 0.726 |
KIAA1161 | SYNE3 | ENSP00000297625 | ENSP00000334308 | KIAA1161; Putative glucosidase (By similarity) | spectrin repeat containing, nuclear envelope family member 3; Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is requ [...] | 0.694 |
KIAA1161 | TOR1AIP2 | ENSP00000297625 | ENSP00000356584 | KIAA1161; Putative glucosidase (By similarity) | torsin A interacting protein 2; Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope | 0.752 |
PPAPDC3 | ERLIN2 | ENSP00000361338 | ENSP00000276461 | phosphatidic acid phosphatase type 2 domain containing 3; Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity (By similarity) | ER lipid raft associated 2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway | 0.517 |
PPAPDC3 | KIAA1161 | ENSP00000361338 | ENSP00000297625 | phosphatidic acid phosphatase type 2 domain containing 3; Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity (By similarity) | KIAA1161; Putative glucosidase (By similarity) | 0.726 |
PPAPDC3 | SYNE3 | ENSP00000361338 | ENSP00000334308 | phosphatidic acid phosphatase type 2 domain containing 3; Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity (By similarity) | spectrin repeat containing, nuclear envelope family member 3; Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is requ [...] | 0.654 |
PPAPDC3 | TOR1AIP2 | ENSP00000361338 | ENSP00000356584 | phosphatidic acid phosphatase type 2 domain containing 3; Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity (By similarity) | torsin A interacting protein 2; Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope | 0.655 |
SYNE3 | KIAA1161 | ENSP00000334308 | ENSP00000297625 | spectrin repeat containing, nuclear envelope family member 3; Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is requ [...] | KIAA1161; Putative glucosidase (By similarity) | 0.694 |