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SYNE3 SYNE3 C6orf52 C6orf52 KIAA1161 KIAA1161 PPAPDC3 PPAPDC3 TOR1AIP2 TOR1AIP2 ERLIN2 ERLIN2 TOR1A TOR1A UBC UBC USP3 USP3 COPS6 COPS6 COPS5 COPS5
"TOR1AIP2" - torsin A interacting protein 2 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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second shell of interactors
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Known Interactions
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experimentally determined
Predicted Interactions
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fusion edge
gene fusions
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gene co-occurrence
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textmining
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protein homology
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TOR1AIP2torsin A interacting protein 2; Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope (470 aa)    
Predicted Functional Partners:
TOR1A
torsin family 1, member A (torsin A); May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. In the nucleus, displaces the nuclear membrane proteins SUN2, SYNE2 and SYNE3, leaving nuclear pores and SUN1 unchanged (332 aa)
        score_image   score_image   0.989
COPS6
COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis); Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...] (327 aa)
        score_image       0.930
COPS5
COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis); Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via i [...] (334 aa)
        score_image       0.895
USP3
ubiquitin specific peptidase 3; Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin (520 aa)
        score_image   score_image   0.753
KIAA1161
KIAA1161; Putative glucosidase (By similarity) (680 aa)
            score_image   0.752
UBC
ubiquitin C (685 aa)
        score_image       0.721
PPAPDC3
phosphatidic acid phosphatase type 2 domain containing 3; Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity (By similarity) (271 aa)
            score_image   0.655
ERLIN2
ER lipid raft associated 2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway (339 aa)
      score_image     score_image   0.620
C6orf52
chromosome 6 open reading frame 52 (152 aa)
            score_image   0.567
SYNE3
spectrin repeat containing, nuclear envelope family member 3; Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is requ [...] (975 aa)
            score_image   0.502
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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