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PHB2 PHB2 CCL1 CCL1 PDLIM1 PDLIM1 SPTAN1 SPTAN1 TOR1A TOR1A TOR3A TOR3A TOR1AIP1 TOR1AIP1 NOS1AP NOS1AP QSOX1 QSOX1 OLFML2B OLFML2B CEP350 CEP350
"TOR3A" - torsin family 3, member A in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
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Gene Fusion
Cooccurence
Coexpression
Experiments
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Textmining
[Homology]
Score
TOR3Atorsin family 3, member A (397 aa)    
Predicted Functional Partners:
TOR1AIP1
torsin A interacting protein 1 (583 aa)
        score_image   score_image   0.812
CCL1
chemokine (C-C motif) ligand 1; Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8 (96 aa)
            score_image   0.754
SPTAN1
spectrin, alpha, non-erythrocytic 1 (2477 aa)
            score_image   0.650
CEP350
centrosomal protein 350kDa; Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ. Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network. Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (3117 aa)
            score_image   0.610
QSOX1
quiescin Q6 sulfhydryl oxidase 1; Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. In fibroblasts, it may have tumor- suppressing capabilities being involved in growth regulation (747 aa)
            score_image   0.604
OLFML2B
olfactomedin-like 2B (750 aa)
            score_image   0.595
TOR1A
torsin family 1, member A (torsin A); May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. In the nucleus, displaces the nuclear membrane proteins SUN2, SYNE2 and SYNE3, leaving nuclear pores and SUN1 unchanged (332 aa)
        score_image   score_image score_image 0.588
PDLIM1
PDZ and LIM domain 1; Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (329 aa)
            score_image   0.585
PHB2
prohibitin 2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging (299 aa)
            score_image   0.583
NOS1AP
nitric oxide synthase 1 (neuronal) adaptor protein; Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity) (506 aa)
            score_image   0.579
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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