node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EDNRA | F2R | ENSP00000315011 | ENSP00000321326 | endothelin receptor type A | coagulation factor II (thrombin) receptor; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development | 0.925 |
EDNRA | GNRH1 | ENSP00000315011 | ENSP00000276414 | endothelin receptor type A | gonadotropin-releasing hormone 1 (luteinizing-releasing hormone); Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones | 0.954 |
EDNRA | GNRHR | ENSP00000315011 | ENSP00000226413 | endothelin receptor type A | gonadotropin-releasing hormone receptor; Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle- stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol- calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling | 0.907 |
EDNRA | MCHR2 | ENSP00000315011 | ENSP00000281806 | endothelin receptor type A | melanin-concentrating hormone receptor 2; Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis | 0.905 |
EDNRA | NMS | ENSP00000315011 | ENSP00000366061 | endothelin receptor type A | neuromedin S; Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions (By similarity) | 0.903 |
EDNRA | NTSR1 | ENSP00000315011 | ENSP00000359532 | endothelin receptor type A | neurotensin receptor 1 (high affinity); Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol- calcium second messenger system | 0.911 |
EDNRA | OXTR | ENSP00000315011 | ENSP00000324270 | endothelin receptor type A | oxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol- calcium second messenger system | 0.929 |
EDNRA | UTS2D | ENSP00000315011 | ENSP00000340526 | endothelin receptor type A | urotensin 2 domain containing; Potent vasoconstrictor (By similarity) | 0.900 |
EDNRA | XCL1 | ENSP00000315011 | ENSP00000356792 | endothelin receptor type A | chemokine (C motif) ligand 1; Chemotactic activity for lymphocytes but not for monocytes or neutrophils | 0.905 |
EDNRA | XCR1 | ENSP00000315011 | ENSP00000310405 | endothelin receptor type A | chemokine (C motif) receptor 1; Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the intracellular calcium ions level | 0.900 |
F2R | EDNRA | ENSP00000321326 | ENSP00000315011 | coagulation factor II (thrombin) receptor; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development | endothelin receptor type A | 0.925 |
F2R | GNRH1 | ENSP00000321326 | ENSP00000276414 | coagulation factor II (thrombin) receptor; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development | gonadotropin-releasing hormone 1 (luteinizing-releasing hormone); Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones | 0.907 |
F2R | GNRHR | ENSP00000321326 | ENSP00000226413 | coagulation factor II (thrombin) receptor; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development | gonadotropin-releasing hormone receptor; Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle- stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol- calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling | 0.903 |
F2R | MCHR2 | ENSP00000321326 | ENSP00000281806 | coagulation factor II (thrombin) receptor; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development | melanin-concentrating hormone receptor 2; Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis | 0.908 |
F2R | NMS | ENSP00000321326 | ENSP00000366061 | coagulation factor II (thrombin) receptor; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development | neuromedin S; Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions (By similarity) | 0.900 |
F2R | NTSR1 | ENSP00000321326 | ENSP00000359532 | coagulation factor II (thrombin) receptor; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development | neurotensin receptor 1 (high affinity); Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol- calcium second messenger system | 0.925 |
F2R | OXTR | ENSP00000321326 | ENSP00000324270 | coagulation factor II (thrombin) receptor; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development | oxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol- calcium second messenger system | 0.920 |
F2R | UTS2D | ENSP00000321326 | ENSP00000340526 | coagulation factor II (thrombin) receptor; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development | urotensin 2 domain containing; Potent vasoconstrictor (By similarity) | 0.900 |
F2R | XCL1 | ENSP00000321326 | ENSP00000356792 | coagulation factor II (thrombin) receptor; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development | chemokine (C motif) ligand 1; Chemotactic activity for lymphocytes but not for monocytes or neutrophils | 0.905 |
F2R | XCR1 | ENSP00000321326 | ENSP00000310405 | coagulation factor II (thrombin) receptor; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development | chemokine (C motif) receptor 1; Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the intracellular calcium ions level | 0.900 |