node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASIC4 | GPA33 | ENSP00000326627 | ENSP00000356842 | acid-sensing (proton-gated) ion channel family member 4; Probable cation channel with high affinity for sodium. In vitro, has no proton-gated channel activity | glycoprotein A33 (transmembrane); May play a role in cell-cell recognition and signaling | 0.816 |
ASIC4 | HAGH | ENSP00000326627 | ENSP00000380514 | acid-sensing (proton-gated) ion channel family member 4; Probable cation channel with high affinity for sodium. In vitro, has no proton-gated channel activity | hydroxyacylglutathione hydrolase; Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid | 0.752 |
ASIC4 | PNKD | ENSP00000326627 | ENSP00000273077 | acid-sensing (proton-gated) ion channel family member 4; Probable cation channel with high affinity for sodium. In vitro, has no proton-gated channel activity | paroxysmal nonkinesigenic dyskinesia; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway (By similarity) | 0.860 |
ASIC4 | SLC4A3 | ENSP00000326627 | ENSP00000273063 | acid-sensing (proton-gated) ion channel family member 4; Probable cation channel with high affinity for sodium. In vitro, has no proton-gated channel activity | solute carrier family 4, anion exchanger, member 3; Plasma membrane anion exchange protein of wide distribution. Mediates at least a part of the Cl(-)/HCO3(-) exchange in cardiac myocytes. Both BAE3 and CAE3 forms transport Cl(-) | 0.714 |
CYP27A1 | GPA33 | ENSP00000258415 | ENSP00000356842 | cytochrome P450, family 27, subfamily A, polypeptide 1; Catalyzes the first step in the oxidation of the side chain of sterol intermediates; the 27-hydroxylation of 5-beta- cholestane-3-alpha,7-alpha,12-alpha-triol. Has also a vitamin D3- 25-hydroxylase activity | glycoprotein A33 (transmembrane); May play a role in cell-cell recognition and signaling | 0.753 |
CYP27A1 | HSF4 | ENSP00000258415 | ENSP00000264009 | cytochrome P450, family 27, subfamily A, polypeptide 1; Catalyzes the first step in the oxidation of the side chain of sterol intermediates; the 27-hydroxylation of 5-beta- cholestane-3-alpha,7-alpha,12-alpha-triol. Has also a vitamin D3- 25-hydroxylase activity | heat shock transcription factor 4; DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription | 0.742 |
GPA33 | ASIC4 | ENSP00000356842 | ENSP00000326627 | glycoprotein A33 (transmembrane); May play a role in cell-cell recognition and signaling | acid-sensing (proton-gated) ion channel family member 4; Probable cation channel with high affinity for sodium. In vitro, has no proton-gated channel activity | 0.816 |
GPA33 | CYP27A1 | ENSP00000356842 | ENSP00000258415 | glycoprotein A33 (transmembrane); May play a role in cell-cell recognition and signaling | cytochrome P450, family 27, subfamily A, polypeptide 1; Catalyzes the first step in the oxidation of the side chain of sterol intermediates; the 27-hydroxylation of 5-beta- cholestane-3-alpha,7-alpha,12-alpha-triol. Has also a vitamin D3- 25-hydroxylase activity | 0.753 |
GPA33 | GSTP1 | ENSP00000356842 | ENSP00000381607 | glycoprotein A33 (transmembrane); May play a role in cell-cell recognition and signaling | glutathione S-transferase pi 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration | 0.450 |
GPA33 | HAGH | ENSP00000356842 | ENSP00000380514 | glycoprotein A33 (transmembrane); May play a role in cell-cell recognition and signaling | hydroxyacylglutathione hydrolase; Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid | 0.812 |
GPA33 | HSF4 | ENSP00000356842 | ENSP00000264009 | glycoprotein A33 (transmembrane); May play a role in cell-cell recognition and signaling | heat shock transcription factor 4; DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription | 0.746 |
GPA33 | PNKD | ENSP00000356842 | ENSP00000273077 | glycoprotein A33 (transmembrane); May play a role in cell-cell recognition and signaling | paroxysmal nonkinesigenic dyskinesia; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway (By similarity) | 0.868 |
GPA33 | SLC4A3 | ENSP00000356842 | ENSP00000273063 | glycoprotein A33 (transmembrane); May play a role in cell-cell recognition and signaling | solute carrier family 4, anion exchanger, member 3; Plasma membrane anion exchange protein of wide distribution. Mediates at least a part of the Cl(-)/HCO3(-) exchange in cardiac myocytes. Both BAE3 and CAE3 forms transport Cl(-) | 0.418 |
GSTP1 | GPA33 | ENSP00000381607 | ENSP00000356842 | glutathione S-transferase pi 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration | glycoprotein A33 (transmembrane); May play a role in cell-cell recognition and signaling | 0.450 |
HAGH | ASIC4 | ENSP00000380514 | ENSP00000326627 | hydroxyacylglutathione hydrolase; Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid | acid-sensing (proton-gated) ion channel family member 4; Probable cation channel with high affinity for sodium. In vitro, has no proton-gated channel activity | 0.752 |
HAGH | GPA33 | ENSP00000380514 | ENSP00000356842 | hydroxyacylglutathione hydrolase; Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid | glycoprotein A33 (transmembrane); May play a role in cell-cell recognition and signaling | 0.812 |
HSF4 | CYP27A1 | ENSP00000264009 | ENSP00000258415 | heat shock transcription factor 4; DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription | cytochrome P450, family 27, subfamily A, polypeptide 1; Catalyzes the first step in the oxidation of the side chain of sterol intermediates; the 27-hydroxylation of 5-beta- cholestane-3-alpha,7-alpha,12-alpha-triol. Has also a vitamin D3- 25-hydroxylase activity | 0.742 |
HSF4 | GPA33 | ENSP00000264009 | ENSP00000356842 | heat shock transcription factor 4; DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription | glycoprotein A33 (transmembrane); May play a role in cell-cell recognition and signaling | 0.746 |
PNKD | ASIC4 | ENSP00000273077 | ENSP00000326627 | paroxysmal nonkinesigenic dyskinesia; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway (By similarity) | acid-sensing (proton-gated) ion channel family member 4; Probable cation channel with high affinity for sodium. In vitro, has no proton-gated channel activity | 0.860 |
PNKD | GPA33 | ENSP00000273077 | ENSP00000356842 | paroxysmal nonkinesigenic dyskinesia; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway (By similarity) | glycoprotein A33 (transmembrane); May play a role in cell-cell recognition and signaling | 0.868 |