| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CDAN1 | MAEL | ENSP00000348564 | ENSP00000356846 | codanin 1; May acts as a negative regulator of ASF1 in chromatin assembly | maelstrom homolog (Drosophila); Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for localization of germ-cell factors to the meiotic nuag [...] | 0.510 |
| CDAN1 | MTL5 | ENSP00000348564 | ENSP00000255087 | codanin 1; May acts as a negative regulator of ASF1 in chromatin assembly | metallothionein-like 5, testis-specific (tesmin); May have a role in spermatogenesis (Probable) | 0.597 |
| CDAN1 | ZNF473 | ENSP00000348564 | ENSP00000270617 | codanin 1; May acts as a negative regulator of ASF1 in chromatin assembly | zinc finger protein 473; Involved in histone 3’-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3’-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases | 0.588 |
| DDX4 | MAEL | ENSP00000424838 | ENSP00000356846 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 4; May play a role in germ cell development. May play a role in sperm motility | maelstrom homolog (Drosophila); Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for localization of germ-cell factors to the meiotic nuag [...] | 0.545 |
| DDX4 | PIWIL1 | ENSP00000424838 | ENSP00000245255 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 4; May play a role in germ cell development. May play a role in sperm motility | piwi-like 1 (Drosophila); Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer- independent mechanism and are primarily derived from transposons and ot [...] | 0.815 |
| DDX4 | PIWIL2 | ENSP00000424838 | ENSP00000349208 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 4; May play a role in germ cell development. May play a role in sperm motility | piwi-like 2 (Drosophila) | 0.787 |
| DDX4 | PIWIL4 | ENSP00000424838 | ENSP00000299001 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 4; May play a role in germ cell development. May play a role in sperm motility | piwi-like 4 (Drosophila); Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated [...] | 0.786 |
| DTD1 | MAEL | ENSP00000366672 | ENSP00000356846 | D-tyrosyl-tRNA deacylase 1; Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) | maelstrom homolog (Drosophila); Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for localization of germ-cell factors to the meiotic nuag [...] | 0.505 |
| MAEL | CDAN1 | ENSP00000356846 | ENSP00000348564 | maelstrom homolog (Drosophila); Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for localization of germ-cell factors to the meiotic nuag [...] | codanin 1; May acts as a negative regulator of ASF1 in chromatin assembly | 0.510 |
| MAEL | DDX4 | ENSP00000356846 | ENSP00000424838 | maelstrom homolog (Drosophila); Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for localization of germ-cell factors to the meiotic nuag [...] | DEAD (Asp-Glu-Ala-Asp) box polypeptide 4; May play a role in germ cell development. May play a role in sperm motility | 0.545 |
| MAEL | DTD1 | ENSP00000356846 | ENSP00000366672 | maelstrom homolog (Drosophila); Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for localization of germ-cell factors to the meiotic nuag [...] | D-tyrosyl-tRNA deacylase 1; Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) | 0.505 |
| MAEL | MTL5 | ENSP00000356846 | ENSP00000255087 | maelstrom homolog (Drosophila); Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for localization of germ-cell factors to the meiotic nuag [...] | metallothionein-like 5, testis-specific (tesmin); May have a role in spermatogenesis (Probable) | 0.478 |
| MAEL | PIWIL1 | ENSP00000356846 | ENSP00000245255 | maelstrom homolog (Drosophila); Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for localization of germ-cell factors to the meiotic nuag [...] | piwi-like 1 (Drosophila); Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer- independent mechanism and are primarily derived from transposons and ot [...] | 0.507 |
| MAEL | PIWIL2 | ENSP00000356846 | ENSP00000349208 | maelstrom homolog (Drosophila); Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for localization of germ-cell factors to the meiotic nuag [...] | piwi-like 2 (Drosophila) | 0.488 |
| MAEL | PIWIL4 | ENSP00000356846 | ENSP00000299001 | maelstrom homolog (Drosophila); Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for localization of germ-cell factors to the meiotic nuag [...] | piwi-like 4 (Drosophila); Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated [...] | 0.460 |
| MAEL | SERPINF2 | ENSP00000356846 | ENSP00000321853 | maelstrom homolog (Drosophila); Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for localization of germ-cell factors to the meiotic nuag [...] | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2; Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin | 0.507 |
| MAEL | SFT2D3 | ENSP00000356846 | ENSP00000310803 | maelstrom homolog (Drosophila); Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for localization of germ-cell factors to the meiotic nuag [...] | SFT2 domain containing 3; May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex (By similarity) | 0.472 |
| MAEL | ZNF473 | ENSP00000356846 | ENSP00000270617 | maelstrom homolog (Drosophila); Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for localization of germ-cell factors to the meiotic nuag [...] | zinc finger protein 473; Involved in histone 3’-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3’-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases | 0.456 |
| MTL5 | CDAN1 | ENSP00000255087 | ENSP00000348564 | metallothionein-like 5, testis-specific (tesmin); May have a role in spermatogenesis (Probable) | codanin 1; May acts as a negative regulator of ASF1 in chromatin assembly | 0.597 |
| MTL5 | MAEL | ENSP00000255087 | ENSP00000356846 | metallothionein-like 5, testis-specific (tesmin); May have a role in spermatogenesis (Probable) | maelstrom homolog (Drosophila); Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for localization of germ-cell factors to the meiotic nuag [...] | 0.478 |
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