POGK protein (Homo sapiens) - STRING network view

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POGK

pogo transposable element with KRAB domain (609 aa)

Predicted Functional Partners:

UBC

0.645

PGBD1

0.555

PGBD2

0.546

ZNF280A

0.519

hCG_32740

0.495

PGBD3

0.495

UVSSA

0.462

SPTLC3

0.416

ABCE1

0.416

SPTLC2

0.416

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCE1	POGK	ENSP00000296577	ENSP00000356849	ATP-binding cassette, sub-family E (OABP), member 1; Antagonizes the binding of 2-5A (5’-phosphorylated 2’,5’-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly	pogo transposable element with KRAB domain	0.416
ABCE1	SPTLC2	ENSP00000296577	ENSP00000216484	ATP-binding cassette, sub-family E (OABP), member 1; Antagonizes the binding of 2-5A (5’-phosphorylated 2’,5’-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly	serine palmitoyltransferase, long chain base subunit 2; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate	0.688
ABCE1	SPTLC3	ENSP00000296577	ENSP00000381968	ATP-binding cassette, sub-family E (OABP), member 1; Antagonizes the binding of 2-5A (5’-phosphorylated 2’,5’-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly	serine palmitoyltransferase, long chain base subunit 3; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, while the SPTLC1-SPTLC3-SPTSSB has the ability to use a broader range of acyl-CoAs without apparent preference	0.688
ABCE1	UBC	ENSP00000296577	ENSP00000344818	ATP-binding cassette, sub-family E (OABP), member 1; Antagonizes the binding of 2-5A (5’-phosphorylated 2’,5’-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly	ubiquitin C	0.979
PGBD1	POGK	ENSP00000259883	ENSP00000356849	piggyBac transposable element derived 1	pogo transposable element with KRAB domain	0.555
PGBD2	POGK	ENSP00000331643	ENSP00000356849	piggyBac transposable element derived 2	pogo transposable element with KRAB domain	0.546
PGBD3	POGK	ENSP00000363242	ENSP00000356849	piggyBac transposable element derived 3	pogo transposable element with KRAB domain	0.495
POGK	ABCE1	ENSP00000356849	ENSP00000296577	pogo transposable element with KRAB domain	ATP-binding cassette, sub-family E (OABP), member 1; Antagonizes the binding of 2-5A (5’-phosphorylated 2’,5’-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly	0.416
POGK	PGBD1	ENSP00000356849	ENSP00000259883	pogo transposable element with KRAB domain	piggyBac transposable element derived 1	0.555
POGK	PGBD2	ENSP00000356849	ENSP00000331643	pogo transposable element with KRAB domain	piggyBac transposable element derived 2	0.546
POGK	PGBD3	ENSP00000356849	ENSP00000363242	pogo transposable element with KRAB domain	piggyBac transposable element derived 3	0.495
POGK	SPTLC2	ENSP00000356849	ENSP00000216484	pogo transposable element with KRAB domain	serine palmitoyltransferase, long chain base subunit 2; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate	0.416
POGK	SPTLC3	ENSP00000356849	ENSP00000381968	pogo transposable element with KRAB domain	serine palmitoyltransferase, long chain base subunit 3; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, while the SPTLC1-SPTLC3-SPTSSB has the ability to use a broader range of acyl-CoAs without apparent preference	0.416
POGK	UBC	ENSP00000356849	ENSP00000344818	pogo transposable element with KRAB domain	ubiquitin C	0.645
POGK	UVSSA	ENSP00000356849	ENSP00000374501	pogo transposable element with KRAB domain	UV-stimulated scaffold protein A; Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to [...]	0.462
POGK	ZNF280A	ENSP00000356849	ENSP00000302855	pogo transposable element with KRAB domain	zinc finger protein 280A; May function as a transcription factor	0.519
POGK	hCG_32740	ENSP00000356849	ENSP00000387966	pogo transposable element with KRAB domain	PiggyBac transposable element-derived protein 3	0.495
SPTLC2	ABCE1	ENSP00000216484	ENSP00000296577	serine palmitoyltransferase, long chain base subunit 2; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate	ATP-binding cassette, sub-family E (OABP), member 1; Antagonizes the binding of 2-5A (5’-phosphorylated 2’,5’-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly	0.688
SPTLC2	POGK	ENSP00000216484	ENSP00000356849	serine palmitoyltransferase, long chain base subunit 2; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate	pogo transposable element with KRAB domain	0.416
SPTLC2	SPTLC3	ENSP00000216484	ENSP00000381968	serine palmitoyltransferase, long chain base subunit 2; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate	serine palmitoyltransferase, long chain base subunit 3; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, while the SPTLC1-SPTLC3-SPTSSB has the ability to use a broader range of acyl-CoAs without apparent preference	0.902

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