node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGK | UAP1 | ENSP00000347581 | ENSP00000356903 | acylglycerol kinase; Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth | UDP-N-acteylglucosamine pyrophosphorylase 1; Converts UDP and GlcNAc-1-P into UDP-GlcNAc, and UDP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P | 0.714 |
GFPT1 | GNE | ENSP00000354347 | ENSP00000379839 | glutamine--fructose-6-phosphate transaminase 1; Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | 0.449 |
GFPT1 | GNPNAT1 | ENSP00000354347 | ENSP00000216410 | glutamine--fructose-6-phosphate transaminase 1; Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins | glucosamine-phosphate N-acetyltransferase 1 | 0.960 |
GFPT1 | PGM3 | ENSP00000354347 | ENSP00000425809 | glutamine--fructose-6-phosphate transaminase 1; Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins | phosphoglucomutase 3 | 0.752 |
GFPT1 | UAP1 | ENSP00000354347 | ENSP00000356903 | glutamine--fructose-6-phosphate transaminase 1; Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins | UDP-N-acteylglucosamine pyrophosphorylase 1; Converts UDP and GlcNAc-1-P into UDP-GlcNAc, and UDP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P | 0.645 |
GFPT1 | UBC | ENSP00000354347 | ENSP00000344818 | glutamine--fructose-6-phosphate transaminase 1; Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins | ubiquitin C | 0.973 |
GNE | GFPT1 | ENSP00000379839 | ENSP00000354347 | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | glutamine--fructose-6-phosphate transaminase 1; Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins | 0.449 |
GNE | PGM3 | ENSP00000379839 | ENSP00000425809 | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | phosphoglucomutase 3 | 0.554 |
GNE | UAP1 | ENSP00000379839 | ENSP00000356903 | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | UDP-N-acteylglucosamine pyrophosphorylase 1; Converts UDP and GlcNAc-1-P into UDP-GlcNAc, and UDP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P | 0.931 |
GNE | UBC | ENSP00000379839 | ENSP00000344818 | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | ubiquitin C | 0.835 |
GNPNAT1 | GFPT1 | ENSP00000216410 | ENSP00000354347 | glucosamine-phosphate N-acetyltransferase 1 | glutamine--fructose-6-phosphate transaminase 1; Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins | 0.960 |
GNPNAT1 | PGM3 | ENSP00000216410 | ENSP00000425809 | glucosamine-phosphate N-acetyltransferase 1 | phosphoglucomutase 3 | 0.975 |
GNPNAT1 | UAP1 | ENSP00000216410 | ENSP00000356903 | glucosamine-phosphate N-acetyltransferase 1 | UDP-N-acteylglucosamine pyrophosphorylase 1; Converts UDP and GlcNAc-1-P into UDP-GlcNAc, and UDP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P | 0.774 |
GNPNAT1 | UBC | ENSP00000216410 | ENSP00000344818 | glucosamine-phosphate N-acetyltransferase 1 | ubiquitin C | 0.747 |
PGM3 | GFPT1 | ENSP00000425809 | ENSP00000354347 | phosphoglucomutase 3 | glutamine--fructose-6-phosphate transaminase 1; Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins | 0.752 |
PGM3 | GNE | ENSP00000425809 | ENSP00000379839 | phosphoglucomutase 3 | glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | 0.554 |
PGM3 | GNPNAT1 | ENSP00000425809 | ENSP00000216410 | phosphoglucomutase 3 | glucosamine-phosphate N-acetyltransferase 1 | 0.975 |
PGM3 | UAP1 | ENSP00000425809 | ENSP00000356903 | phosphoglucomutase 3 | UDP-N-acteylglucosamine pyrophosphorylase 1; Converts UDP and GlcNAc-1-P into UDP-GlcNAc, and UDP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P | 0.978 |
PGM3 | UBC | ENSP00000425809 | ENSP00000344818 | phosphoglucomutase 3 | ubiquitin C | 0.891 |
SLC37A1 | UAP1 | ENSP00000344648 | ENSP00000356903 | solute carrier family 37 (glycerol-3-phosphate transporter), member 1 | UDP-N-acteylglucosamine pyrophosphorylase 1; Converts UDP and GlcNAc-1-P into UDP-GlcNAc, and UDP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P | 0.685 |