node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CPLX3 | MOXD1 | ENSP00000378464 | ENSP00000356940 | complexin 3; Positively regulates a late step in synaptic vesicle exocytosis (By similarity) | monooxygenase, DBH-like 1 | 0.540 |
EIF1B | MOXD1 | ENSP00000232905 | ENSP00000356940 | eukaryotic translation initiation factor 1B; Probably involved in translation | monooxygenase, DBH-like 1 | 0.621 |
EPGN | MOXD1 | ENSP00000330375 | ENSP00000356940 | epithelial mitogen homolog (mouse); Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases | monooxygenase, DBH-like 1 | 0.675 |
L3MBTL3 | MOXD1 | ENSP00000354526 | ENSP00000356940 | l(3)mbt-like 3 (Drosophila); Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Required for normal maturation of myeloid progenitor cells (By similarity) | monooxygenase, DBH-like 1 | 0.609 |
MOXD1 | CPLX3 | ENSP00000356940 | ENSP00000378464 | monooxygenase, DBH-like 1 | complexin 3; Positively regulates a late step in synaptic vesicle exocytosis (By similarity) | 0.540 |
MOXD1 | EIF1B | ENSP00000356940 | ENSP00000232905 | monooxygenase, DBH-like 1 | eukaryotic translation initiation factor 1B; Probably involved in translation | 0.621 |
MOXD1 | EPGN | ENSP00000356940 | ENSP00000330375 | monooxygenase, DBH-like 1 | epithelial mitogen homolog (mouse); Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases | 0.675 |
MOXD1 | L3MBTL3 | ENSP00000356940 | ENSP00000354526 | monooxygenase, DBH-like 1 | l(3)mbt-like 3 (Drosophila); Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Required for normal maturation of myeloid progenitor cells (By similarity) | 0.609 |
MOXD1 | SEPT2 | ENSP00000356940 | ENSP00000353157 | monooxygenase, DBH-like 1 | septin 2; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongat [...] | 0.486 |
MOXD1 | SMAD7 | ENSP00000356940 | ENSP00000262158 | monooxygenase, DBH-like 1 | SMAD family member 7; Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A- PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator ( [...] | 0.800 |
MOXD1 | STX7 | ENSP00000356940 | ENSP00000356918 | monooxygenase, DBH-like 1 | syntaxin 7; May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes | 0.860 |
MOXD1 | TAAR5 | ENSP00000356940 | ENSP00000258034 | monooxygenase, DBH-like 1 | trace amine associated receptor 5; Orphan receptor. Ligands are likely small molecules, either sharing some similarities with trace amine as, e.g. derivatives of indolamines (such as 5-methoxytryptamine) or of phenylethylamines (such as phenylethanolamine) or being any kind of metabolite of amino acids or biogenic amine neurotransmitters | 0.760 |
MOXD1 | TAAR6 | ENSP00000356940 | ENSP00000275198 | monooxygenase, DBH-like 1 | trace amine associated receptor 6; Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood | 0.752 |
MOXD1 | WDR5 | ENSP00000356940 | ENSP00000351446 | monooxygenase, DBH-like 1 | WD repeat domain 5; Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at ’Lys-4’. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at ’Lys-4’ of histone H3. H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation | 0.588 |
SEPT2 | MOXD1 | ENSP00000353157 | ENSP00000356940 | septin 2; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongat [...] | monooxygenase, DBH-like 1 | 0.486 |
SMAD7 | MOXD1 | ENSP00000262158 | ENSP00000356940 | SMAD family member 7; Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A- PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator ( [...] | monooxygenase, DBH-like 1 | 0.800 |
STX7 | MOXD1 | ENSP00000356918 | ENSP00000356940 | syntaxin 7; May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes | monooxygenase, DBH-like 1 | 0.860 |
STX7 | TAAR5 | ENSP00000356918 | ENSP00000258034 | syntaxin 7; May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes | trace amine associated receptor 5; Orphan receptor. Ligands are likely small molecules, either sharing some similarities with trace amine as, e.g. derivatives of indolamines (such as 5-methoxytryptamine) or of phenylethylamines (such as phenylethanolamine) or being any kind of metabolite of amino acids or biogenic amine neurotransmitters | 0.620 |
STX7 | TAAR6 | ENSP00000356918 | ENSP00000275198 | syntaxin 7; May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes | trace amine associated receptor 6; Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood | 0.568 |
TAAR5 | MOXD1 | ENSP00000258034 | ENSP00000356940 | trace amine associated receptor 5; Orphan receptor. Ligands are likely small molecules, either sharing some similarities with trace amine as, e.g. derivatives of indolamines (such as 5-methoxytryptamine) or of phenylethylamines (such as phenylethanolamine) or being any kind of metabolite of amino acids or biogenic amine neurotransmitters | monooxygenase, DBH-like 1 | 0.760 |