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ADAM17 ADAM17 IGSF11 IGSF11 PARD3 PARD3 TMPRSS11E TMPRSS11E PVRL4 PVRL4 PVRL3 PVRL3 PVRL2 PVRL2 PVRL1 PVRL1 TAPBPL TAPBPL MLLT4 MLLT4 SLAMF1 SLAMF1
"PVRL4" - poliovirus receptor-related 4 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
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experimentally determined
Predicted Interactions
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fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Score
PVRL4poliovirus receptor-related 4; Seems to be involved in cell adhesion through trans- homophilic and -heterophilic interactions, the latter including specifically interactions with PVRL2/nectin-1. Does not act as receptor for alpha-herpesvirus entry into cells (510 aa)    
Predicted Functional Partners:
MLLT4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 (1651 aa)
         score_image score_image score_image   0.996
PVRL1
poliovirus receptor-related 1 (herpesvirus entry mediator C); Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between PVRL1/nectin-1 and PVRL3/nectin-3 and between PVRL1/nectin-1 and PVRL4/nectin-4 (517 aa)
         score_image score_image score_image score_image 0.990
IGSF11
immunoglobulin superfamily, member 11; Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth (431 aa)
         score_image       0.960
TAPBPL
TAP binding protein-like (468 aa)
         score_image       0.960
PVRL2
poliovirus receptor-related 2 (herpesvirus entry mediator B); Probable cell adhesion protein (538 aa)
         score_image score_image score_image score_image 0.949
PVRL3
poliovirus receptor-related 3; Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. P [...] (549 aa)
         score_image score_image score_image score_image 0.929
PARD3
par-3 partitioning defective 3 homolog (C. elegans) (1356 aa)
           score_image score_image   0.800
TMPRSS11E
transmembrane protease, serine 11E; Serine protease which possesses both gelatinolytic and caseinolytic activities. Shows a preference for Arg in the P1 position (By similarity) (423 aa)
             score_image   0.628
SLAMF1
signaling lymphocytic activation molecule family member 1; High-affinity self-ligand important in bidirectional T- cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist- one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates (335 aa)
             score_image   0.620
ADAM17
ADAM metallopeptidase domain 17; Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway (By similarity) (824 aa)
             score_image   0.606
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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