node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCD3 | PEX11A | ENSP00000359233 | ENSP00000300056 | ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | peroxisomal biogenesis factor 11 alpha; May be involved in peroxisomal proliferation and may regulate peroxisomes division. May mediate binding of coatomer proteins to the peroxisomal membrane | 0.810 |
ABCD3 | PEX12 | ENSP00000359233 | ENSP00000225873 | ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | peroxisomal biogenesis factor 12; Required for protein import into peroxisomes | 0.560 |
ABCD3 | PEX13 | ENSP00000359233 | ENSP00000295030 | ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | peroxisomal biogenesis factor 13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins | 0.779 |
ABCD3 | PEX14 | ENSP00000359233 | ENSP00000349016 | ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | peroxisomal biogenesis factor 14; Component of the peroxisomal translocation machinery with PEX13 and PEX17. Interacts with both the PTS1 and PTS2 receptors. Binds directly to PEX17 | 0.922 |
ABCD3 | PEX16 | ENSP00000359233 | ENSP00000241041 | ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | peroxisomal biogenesis factor 16; Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3 | 0.741 |
ABCD3 | PEX19 | ENSP00000359233 | ENSP00000357051 | ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | peroxisomal biogenesis factor 19; Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53 | 0.999 |
ABCD3 | PEX2 | ENSP00000359233 | ENSP00000349543 | ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | peroxisomal biogenesis factor 2; Somewhat implicated in the biogenesis of peroxisomes | 0.588 |
ABCD3 | PEX3 | ENSP00000359233 | ENSP00000356563 | ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | peroxisomal biogenesis factor 3; Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes | 0.956 |
ABCD3 | SLC25A17 | ENSP00000359233 | ENSP00000390722 | ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17; Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extend for nicotinamide adenine dinucleotide (NAD(+)), adenosine diphosphate (ADP) and adenosine 3’,5’- diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD(+) from the cytosol into the peroxisomal matrix by a counter- exchange mechanism. Inhibited by pyridoxal 5’-phosphate and ba [...] | 0.936 |
PEX10 | PEX11A | ENSP00000288774 | ENSP00000300056 | peroxisomal biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes | peroxisomal biogenesis factor 11 alpha; May be involved in peroxisomal proliferation and may regulate peroxisomes division. May mediate binding of coatomer proteins to the peroxisomal membrane | 0.895 |
PEX10 | PEX12 | ENSP00000288774 | ENSP00000225873 | peroxisomal biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes | peroxisomal biogenesis factor 12; Required for protein import into peroxisomes | 0.999 |
PEX10 | PEX13 | ENSP00000288774 | ENSP00000295030 | peroxisomal biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes | peroxisomal biogenesis factor 13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins | 0.993 |
PEX10 | PEX14 | ENSP00000288774 | ENSP00000349016 | peroxisomal biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes | peroxisomal biogenesis factor 14; Component of the peroxisomal translocation machinery with PEX13 and PEX17. Interacts with both the PTS1 and PTS2 receptors. Binds directly to PEX17 | 0.975 |
PEX10 | PEX16 | ENSP00000288774 | ENSP00000241041 | peroxisomal biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes | peroxisomal biogenesis factor 16; Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3 | 0.859 |
PEX10 | PEX19 | ENSP00000288774 | ENSP00000357051 | peroxisomal biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes | peroxisomal biogenesis factor 19; Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53 | 0.998 |
PEX10 | PEX2 | ENSP00000288774 | ENSP00000349543 | peroxisomal biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes | peroxisomal biogenesis factor 2; Somewhat implicated in the biogenesis of peroxisomes | 0.997 |
PEX10 | PEX3 | ENSP00000288774 | ENSP00000356563 | peroxisomal biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes | peroxisomal biogenesis factor 3; Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes | 0.892 |
PEX10 | SLC25A17 | ENSP00000288774 | ENSP00000390722 | peroxisomal biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes | solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17; Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extend for nicotinamide adenine dinucleotide (NAD(+)), adenosine diphosphate (ADP) and adenosine 3’,5’- diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD(+) from the cytosol into the peroxisomal matrix by a counter- exchange mechanism. Inhibited by pyridoxal 5’-phosphate and ba [...] | 0.519 |
PEX11A | ABCD3 | ENSP00000300056 | ENSP00000359233 | peroxisomal biogenesis factor 11 alpha; May be involved in peroxisomal proliferation and may regulate peroxisomes division. May mediate binding of coatomer proteins to the peroxisomal membrane | ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | 0.810 |
PEX11A | PEX10 | ENSP00000300056 | ENSP00000288774 | peroxisomal biogenesis factor 11 alpha; May be involved in peroxisomal proliferation and may regulate peroxisomes division. May mediate binding of coatomer proteins to the peroxisomal membrane | peroxisomal biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes | 0.895 |