node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C20orf72 | CCDC19 | ENSP00000366939 | ENSP00000357079 | chromosome 20 open reading frame 72; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5’-3’ exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair | coiled-coil domain containing 19 | 0.618 |
CCDC19 | C20orf72 | ENSP00000357079 | ENSP00000366939 | coiled-coil domain containing 19 | chromosome 20 open reading frame 72; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5’-3’ exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair | 0.618 |
CCDC19 | COIL | ENSP00000357079 | ENSP00000240316 | coiled-coil domain containing 19 | coilin; Is a component of the nuclear coiled bodies (CBS) which are involved in the function or assembly/disassembly of nucleoplasmic snRNPs. During mitosis, CBS disassemble, coinciding with a mitotic-specific phosphorylation of p80 coilin | 0.681 |
CCDC19 | DAG1 | ENSP00000357079 | ENSP00000312435 | coiled-coil domain containing 19 | dystroglycan 1 (dystrophin-associated glycoprotein 1); The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization | 0.439 |
CCDC19 | ENSG00000257411 | ENSP00000357079 | ENSP00000449770 | coiled-coil domain containing 19 | Uncharacterized protein | 0.595 |
CCDC19 | FAM3C | ENSP00000357079 | ENSP00000353025 | coiled-coil domain containing 19 | family with sequence similarity 3, member C; May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition | 0.460 |
CCDC19 | FSTL1 | ENSP00000357079 | ENSP00000295633 | coiled-coil domain containing 19 | follistatin-like 1; May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin (By similarity) | 0.449 |
CCDC19 | GM2A | ENSP00000357079 | ENSP00000349687 | coiled-coil domain containing 19 | GM2 ganglioside activator; The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta- hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3 | 0.494 |
CCDC19 | PA2G4 | ENSP00000357079 | ENSP00000302886 | coiled-coil domain containing 19 | proliferation-associated 2G4, 38kDa; May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in [...] | 0.654 |
CCDC19 | SULT2B1 | ENSP00000357079 | ENSP00000201586 | coiled-coil domain containing 19 | sulfotransferase family, cytosolic, 2B, member 1; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol | 0.561 |
COIL | CCDC19 | ENSP00000240316 | ENSP00000357079 | coilin; Is a component of the nuclear coiled bodies (CBS) which are involved in the function or assembly/disassembly of nucleoplasmic snRNPs. During mitosis, CBS disassemble, coinciding with a mitotic-specific phosphorylation of p80 coilin | coiled-coil domain containing 19 | 0.681 |
DAG1 | CCDC19 | ENSP00000312435 | ENSP00000357079 | dystroglycan 1 (dystrophin-associated glycoprotein 1); The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization | coiled-coil domain containing 19 | 0.439 |
ENSG00000257411 | CCDC19 | ENSP00000449770 | ENSP00000357079 | Uncharacterized protein | coiled-coil domain containing 19 | 0.595 |
FAM3C | CCDC19 | ENSP00000353025 | ENSP00000357079 | family with sequence similarity 3, member C; May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition | coiled-coil domain containing 19 | 0.460 |
FSTL1 | CCDC19 | ENSP00000295633 | ENSP00000357079 | follistatin-like 1; May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin (By similarity) | coiled-coil domain containing 19 | 0.449 |
GM2A | CCDC19 | ENSP00000349687 | ENSP00000357079 | GM2 ganglioside activator; The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta- hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3 | coiled-coil domain containing 19 | 0.494 |
PA2G4 | CCDC19 | ENSP00000302886 | ENSP00000357079 | proliferation-associated 2G4, 38kDa; May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in [...] | coiled-coil domain containing 19 | 0.654 |
SULT2B1 | CCDC19 | ENSP00000201586 | ENSP00000357079 | sulfotransferase family, cytosolic, 2B, member 1; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol | coiled-coil domain containing 19 | 0.561 |