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FYB FYB CCRL1 CCRL1 DARC DARC CCL8 CCL8 CCL7 CCL7 CXCL1 CXCL1 CCL2 CCL2 IL8 IL8 CCL17 CCL17 CCL5 CCL5 CXCL5 CXCL5
"DARC" - Duffy blood group, chemokine receptor in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
DARCDuffy blood group, chemokine receptor (338 aa)    
Predicted Functional Partners:
IL8
interleukin 8 (99 aa)
        score_image score_image score_image   0.997
CCL2
chemokine (C-C motif) ligand 2; Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis (99 aa)
        score_image   score_image   0.883
CXCL1
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha); Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO- alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity (107 aa)
        score_image   score_image   0.882
CCL5
chemokine (C-C motif) ligand 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. Binds to CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T- cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exh [...] (91 aa)
        score_image   score_image   0.741
CCRL1
chemokine (C-C motif) receptor-like 1; Receptor for CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25 (350 aa)
            score_image   0.700
CCL7
chemokine (C-C motif) ligand 7; Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3 (99 aa)
        score_image   score_image   0.667
FYB
FYN binding protein; Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (829 aa)
            score_image   0.644
CXCL5
chemokine (C-X-C motif) ligand 5; Involved in neutrophil activation. In vitro, ENA-78(8- 78) and ENA-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes (114 aa)
        score_image   score_image   0.641
CCL8
chemokine (C-C motif) ligand 8; Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind heparin. The processed form MCP-2(6-76) does not show monocyte chemotactic activity, but inhibits the chemotactic effect most predominantly of CCL7, and also of CCL2 and CCL5 and CCL8 (99 aa)
        score_image       0.567
CCL17
chemokine (C-C motif) ligand 17; Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4 (94 aa)
        score_image       0.567
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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