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MPP3 MPP3 MLLT4 MLLT4 PVRL3 PVRL3 EPB41L3 EPB41L3 CADM1 CADM1 PVRL1 PVRL1 CADM3 CADM3 DLG3 DLG3 MPP6 MPP6 EPB41L1 EPB41L1
"CADM3" - cell adhesion molecule 3 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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second shell of interactors
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CADM3cell adhesion molecule 3; Involved in the cell-cell adhesion. Has both calcium- independent homophilic cell-cell adhesion activity and calcium- independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity) (432 aa)    
Predicted Functional Partners:
MPP3
membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) (585 aa)
            score_image   0.929
PVRL3
poliovirus receptor-related 3; Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. P [...] (549 aa)
          score_image score_image score_image 0.924
PVRL1
poliovirus receptor-related 1 (herpesvirus entry mediator C); Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between PVRL1/nectin-1 and PVRL3/nectin-3 and between PVRL1/nectin-1 and PVRL4/nectin-4 (517 aa)
          score_image score_image score_image 0.920
DLG3
discs, large homolog 3 (Drosophila); Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling (817 aa)
            score_image   0.917
CADM1
cell adhesion molecule 1; Mediates homophilic cell-cell adhesion in a Ca(2+)- independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachme [...] (442 aa)
          score_image score_image score_image 0.913
MPP6
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) (540 aa)
            score_image   0.746
MLLT4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 (1651 aa)
            score_image   0.489
EPB41L1
erythrocyte membrane protein band 4.1-like 1 (881 aa)
        score_image   score_image   0.460
EPB41L3
erythrocyte membrane protein band 4.1-like 3; Critical growth regulator in the pathogenesis of meningiomas (1087 aa)
        score_image   score_image   0.439
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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