node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCG5 | CD5L | ENSP00000260645 | ENSP00000357156 | ATP-binding cassette, sub-family G (WHITE), member 5; Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile | CD5 molecule-like; May play a role in the regulation of the immune system. Seems to play a role as an inhibitor of apoptosis | 0.410 |
ABCG5 | NR1H2 | ENSP00000260645 | ENSP00000253727 | ATP-binding cassette, sub-family G (WHITE), member 5; Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile | nuclear receptor subfamily 1, group H, member 2; Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5’-AGGTCA-3’ and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity) | 0.784 |
ABCG5 | SLCO1B1 | ENSP00000260645 | ENSP00000256958 | ATP-binding cassette, sub-family G (WHITE), member 5; Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile | solute carrier organic anion transporter family, member 1B1; Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver | 0.654 |
ALCAM | CD5L | ENSP00000305988 | ENSP00000357156 | activated leukocyte cell adhesion molecule; Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via heterophilic and homophilic interactions. May play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the nervous system | CD5 molecule-like; May play a role in the regulation of the immune system. Seems to play a role as an inhibitor of apoptosis | 0.408 |
C17orf59 | CD5L | ENSP00000373669 | ENSP00000357156 | chromosome 17 open reading frame 59 | CD5 molecule-like; May play a role in the regulation of the immune system. Seems to play a role as an inhibitor of apoptosis | 0.471 |
CD40LG | CD5 | ENSP00000359663 | ENSP00000342681 | CD40 ligand; Mediates B-cell proliferation in the absence of co- stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching | CD5 molecule; May act as a receptor in regulating T-cell proliferation | 0.839 |
CD40LG | CD5L | ENSP00000359663 | ENSP00000357156 | CD40 ligand; Mediates B-cell proliferation in the absence of co- stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching | CD5 molecule-like; May play a role in the regulation of the immune system. Seems to play a role as an inhibitor of apoptosis | 0.646 |
CD5 | CD40LG | ENSP00000342681 | ENSP00000359663 | CD5 molecule; May act as a receptor in regulating T-cell proliferation | CD40 ligand; Mediates B-cell proliferation in the absence of co- stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching | 0.839 |
CD5 | CD5L | ENSP00000342681 | ENSP00000357156 | CD5 molecule; May act as a receptor in regulating T-cell proliferation | CD5 molecule-like; May play a role in the regulation of the immune system. Seems to play a role as an inhibitor of apoptosis | 0.513 |
CD5L | ABCG5 | ENSP00000357156 | ENSP00000260645 | CD5 molecule-like; May play a role in the regulation of the immune system. Seems to play a role as an inhibitor of apoptosis | ATP-binding cassette, sub-family G (WHITE), member 5; Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile | 0.410 |
CD5L | ALCAM | ENSP00000357156 | ENSP00000305988 | CD5 molecule-like; May play a role in the regulation of the immune system. Seems to play a role as an inhibitor of apoptosis | activated leukocyte cell adhesion molecule; Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via heterophilic and homophilic interactions. May play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the nervous system | 0.408 |
CD5L | C17orf59 | ENSP00000357156 | ENSP00000373669 | CD5 molecule-like; May play a role in the regulation of the immune system. Seems to play a role as an inhibitor of apoptosis | chromosome 17 open reading frame 59 | 0.471 |
CD5L | CD40LG | ENSP00000357156 | ENSP00000359663 | CD5 molecule-like; May play a role in the regulation of the immune system. Seems to play a role as an inhibitor of apoptosis | CD40 ligand; Mediates B-cell proliferation in the absence of co- stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching | 0.646 |
CD5L | CD5 | ENSP00000357156 | ENSP00000342681 | CD5 molecule-like; May play a role in the regulation of the immune system. Seems to play a role as an inhibitor of apoptosis | CD5 molecule; May act as a receptor in regulating T-cell proliferation | 0.513 |
CD5L | NR1H2 | ENSP00000357156 | ENSP00000253727 | CD5 molecule-like; May play a role in the regulation of the immune system. Seems to play a role as an inhibitor of apoptosis | nuclear receptor subfamily 1, group H, member 2; Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5’-AGGTCA-3’ and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity) | 0.510 |
CD5L | SLCO1B1 | ENSP00000357156 | ENSP00000256958 | CD5 molecule-like; May play a role in the regulation of the immune system. Seems to play a role as an inhibitor of apoptosis | solute carrier organic anion transporter family, member 1B1; Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver | 0.487 |
CD5L | SPTB | ENSP00000357156 | ENSP00000374372 | CD5 molecule-like; May play a role in the regulation of the immune system. Seems to play a role as an inhibitor of apoptosis | spectrin, beta, erythrocytic; Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane | 0.562 |
CD5L | UGT1A1 | ENSP00000357156 | ENSP00000304845 | CD5 molecule-like; May play a role in the regulation of the immune system. Seems to play a role as an inhibitor of apoptosis | UDP glucuronosyltransferase 1 family, polypeptide A1; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4- methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone | 0.644 |
CD5L | UGT1A6 | ENSP00000357156 | ENSP00000303174 | CD5 molecule-like; May play a role in the regulation of the immune system. Seems to play a role as an inhibitor of apoptosis | UDP glucuronosyltransferase 1 family, polypeptide A6; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols | 0.680 |
NR1H2 | ABCG5 | ENSP00000253727 | ENSP00000260645 | nuclear receptor subfamily 1, group H, member 2; Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5’-AGGTCA-3’ and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity) | ATP-binding cassette, sub-family G (WHITE), member 5; Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile | 0.784 |