FCRL3 protein (Homo sapiens) - STRING network view

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FCRL3

Fc receptor-like 3 (734 aa)

Predicted Functional Partners:

PIGR

0.750

PTPN22

0.720

PTPN11

0.674

PADI4

0.643

SYK

0.635

ZAP70

0.606

TSHR

0.561

CTLA4

0.514

MUC1

0.511

SULT2B1

0.489

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTLA4	FCRL3	ENSP00000303939	ENSP00000357167	cytotoxic T-lymphocyte-associated protein 4	Fc receptor-like 3	0.514
CTLA4	PADI4	ENSP00000303939	ENSP00000364597	cytotoxic T-lymphocyte-associated protein 4	peptidyl arginine deiminase, type IV; Catalyzes the citrullination/deimination of arginine residues of proteins. Citrullinates histone H3 at ’Arg-8’ and/or ’Arg-17’ and histone H4 at ’Arg-3’, which prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at ’Arg-2142’, which favors its interaction with NCOA2/GRIP1	0.585
CTLA4	PTPN11	ENSP00000303939	ENSP00000340944	cytotoxic T-lymphocyte-associated protein 4	protein tyrosine phosphatase, non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity	0.977
CTLA4	PTPN22	ENSP00000303939	ENSP00000352833	cytotoxic T-lymphocyte-associated protein 4	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.961
CTLA4	TSHR	ENSP00000303939	ENSP00000298171	cytotoxic T-lymphocyte-associated protein 4	thyroid stimulating hormone receptor	0.507
CTLA4	ZAP70	ENSP00000303939	ENSP00000264972	cytotoxic T-lymphocyte-associated protein 4	zeta-chain (TCR) associated protein kinase 70kDa; Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Contributes also to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization t [...]	0.601
FCRL3	CTLA4	ENSP00000357167	ENSP00000303939	Fc receptor-like 3	cytotoxic T-lymphocyte-associated protein 4	0.514
FCRL3	MUC1	ENSP00000357167	ENSP00000357380	Fc receptor-like 3	mucin 1, cell surface associated	0.511
FCRL3	PADI4	ENSP00000357167	ENSP00000364597	Fc receptor-like 3	peptidyl arginine deiminase, type IV; Catalyzes the citrullination/deimination of arginine residues of proteins. Citrullinates histone H3 at ’Arg-8’ and/or ’Arg-17’ and histone H4 at ’Arg-3’, which prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at ’Arg-2142’, which favors its interaction with NCOA2/GRIP1	0.643
FCRL3	PIGR	ENSP00000357167	ENSP00000348888	Fc receptor-like 3	polymeric immunoglobulin receptor; This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment	0.750
FCRL3	PTPN11	ENSP00000357167	ENSP00000340944	Fc receptor-like 3	protein tyrosine phosphatase, non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity	0.674
FCRL3	PTPN22	ENSP00000357167	ENSP00000352833	Fc receptor-like 3	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.720
FCRL3	SULT2B1	ENSP00000357167	ENSP00000201586	Fc receptor-like 3	sulfotransferase family, cytosolic, 2B, member 1; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol	0.489
FCRL3	SYK	ENSP00000357167	ENSP00000364898	Fc receptor-like 3	spleen tyrosine kinase; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine- phosphorylated ITAM domains. The association with the receptor can also [...]	0.635
FCRL3	TSHR	ENSP00000357167	ENSP00000298171	Fc receptor-like 3	thyroid stimulating hormone receptor	0.561
FCRL3	ZAP70	ENSP00000357167	ENSP00000264972	Fc receptor-like 3	zeta-chain (TCR) associated protein kinase 70kDa; Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Contributes also to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization t [...]	0.606
MUC1	FCRL3	ENSP00000357380	ENSP00000357167	mucin 1, cell surface associated	Fc receptor-like 3	0.511
MUC1	ZAP70	ENSP00000357380	ENSP00000264972	mucin 1, cell surface associated	zeta-chain (TCR) associated protein kinase 70kDa; Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Contributes also to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization t [...]	0.913
PADI4	CTLA4	ENSP00000364597	ENSP00000303939	peptidyl arginine deiminase, type IV; Catalyzes the citrullination/deimination of arginine residues of proteins. Citrullinates histone H3 at ’Arg-8’ and/or ’Arg-17’ and histone H4 at ’Arg-3’, which prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at ’Arg-2142’, which favors its interaction with NCOA2/GRIP1	cytotoxic T-lymphocyte-associated protein 4	0.585
PADI4	FCRL3	ENSP00000364597	ENSP00000357167	peptidyl arginine deiminase, type IV; Catalyzes the citrullination/deimination of arginine residues of proteins. Citrullinates histone H3 at ’Arg-8’ and/or ’Arg-17’ and histone H4 at ’Arg-3’, which prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at ’Arg-2142’, which favors its interaction with NCOA2/GRIP1	Fc receptor-like 3	0.643

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