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PRKG2 PRKG2 PEX5L PEX5L KCNK13 KCNK13 KCNE2 KCNE2 HCN3 HCN3 GJA5 GJA5 SCN5A SCN5A YES1 YES1 KCNJ2 KCNJ2 KCND2 KCND2 SRC SRC
"HCN3" - hyperpolarization activated cyclic nucleotide-gated potassium channel 3 in Homo sapiens
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HCN3hyperpolarization activated cyclic nucleotide-gated potassium channel 3; Putative hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions (By similarity) (774 aa)    
Predicted Functional Partners:
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein- coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to f [...] (536 aa)
             score_image   0.789
YES1
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1; Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific j [...] (543 aa)
             score_image   0.691
PEX5L
peroxisomal biogenesis factor 5-like; Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence (By similarity) (626 aa)
         score_image   score_image   0.670
KCNE2
potassium voltage-gated channel, Isk-related family, member 2; Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with KCNQ1/KVLTQ1 and elicit a voltage-independent current. May associate with HCN1 and HC [...] (123 aa)
             score_image   0.654
KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2; Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by inter [...] (427 aa)
             score_image   0.558
GJA5
gap junction protein, alpha 5, 40kDa; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell (358 aa)
             score_image   0.496
SCN5A
sodium channel, voltage-gated, type V, alpha subunit (2016 aa)
             score_image   0.456
KCNK13
potassium channel, subfamily K, member 13; Potassium channel displaying weak inward rectification in symmetrical K(+) solution (By similarity) (408 aa)
             score_image   0.449
PRKG2
protein kinase, cGMP-dependent, type II (762 aa)
             score_image   0.448
KCND2
potassium voltage-gated channel, Shal-related subfamily, member 2; Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits (630 aa)
         score_image   score_image   0.440
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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