PMVK protein (Homo sapiens) - STRING network view

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Score

PMVK

phosphomevalonate kinase (192 aa)

Predicted Functional Partners:

MVK

0.973

MVD

0.970

SREBF2

0.938

NFYC

0.900

NFYA

0.900

SP1

0.900

NFYB

0.900

UBC

0.892

PEX5

0.750

HMGCR

0.744

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HMGCR	MVD	ENSP00000287936	ENSP00000301012	3-hydroxy-3-methylglutaryl-CoA reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins	mevalonate (diphospho) decarboxylase; Performs the first committed step in the biosynthesis of isoprenes	0.809
HMGCR	MVK	ENSP00000287936	ENSP00000228510	3-hydroxy-3-methylglutaryl-CoA reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins	mevalonate kinase; May be a regulatory site in cholesterol biosynthetic pathway	0.987
HMGCR	NFYA	ENSP00000287936	ENSP00000345702	3-hydroxy-3-methylglutaryl-CoA reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins	nuclear transcription factor Y, alpha; Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters, for example in type 1 collagen, albumin and beta-actin genes	0.902
HMGCR	NFYB	ENSP00000287936	ENSP00000240055	3-hydroxy-3-methylglutaryl-CoA reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins	nuclear transcription factor Y, beta; Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters, for example in type 1 collagen, albumin and beta-actin genes	0.901
HMGCR	NFYC	ENSP00000287936	ENSP00000396620	3-hydroxy-3-methylglutaryl-CoA reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins	nuclear transcription factor Y, gamma	0.900
HMGCR	PMVK	ENSP00000287936	ENSP00000357452	3-hydroxy-3-methylglutaryl-CoA reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins	phosphomevalonate kinase	0.744
HMGCR	SREBF2	ENSP00000287936	ENSP00000354476	3-hydroxy-3-methylglutaryl-CoA reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins	sterol regulatory element binding transcription factor 2; Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5’-ATCACCCCAC-3’) found in the flanking region of the LDRL and HMG-CoA synthase genes	0.987
HMGCR	UBC	ENSP00000287936	ENSP00000344818	3-hydroxy-3-methylglutaryl-CoA reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins	ubiquitin C	0.999
MVD	HMGCR	ENSP00000301012	ENSP00000287936	mevalonate (diphospho) decarboxylase; Performs the first committed step in the biosynthesis of isoprenes	3-hydroxy-3-methylglutaryl-CoA reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins	0.809
MVD	MVK	ENSP00000301012	ENSP00000228510	mevalonate (diphospho) decarboxylase; Performs the first committed step in the biosynthesis of isoprenes	mevalonate kinase; May be a regulatory site in cholesterol biosynthetic pathway	0.947
MVD	PMVK	ENSP00000301012	ENSP00000357452	mevalonate (diphospho) decarboxylase; Performs the first committed step in the biosynthesis of isoprenes	phosphomevalonate kinase	0.970
MVD	SREBF2	ENSP00000301012	ENSP00000354476	mevalonate (diphospho) decarboxylase; Performs the first committed step in the biosynthesis of isoprenes	sterol regulatory element binding transcription factor 2; Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5’-ATCACCCCAC-3’) found in the flanking region of the LDRL and HMG-CoA synthase genes	0.932
MVD	UBC	ENSP00000301012	ENSP00000344818	mevalonate (diphospho) decarboxylase; Performs the first committed step in the biosynthesis of isoprenes	ubiquitin C	0.676
MVK	HMGCR	ENSP00000228510	ENSP00000287936	mevalonate kinase; May be a regulatory site in cholesterol biosynthetic pathway	3-hydroxy-3-methylglutaryl-CoA reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins	0.987
MVK	MVD	ENSP00000228510	ENSP00000301012	mevalonate kinase; May be a regulatory site in cholesterol biosynthetic pathway	mevalonate (diphospho) decarboxylase; Performs the first committed step in the biosynthesis of isoprenes	0.947
MVK	NFYA	ENSP00000228510	ENSP00000345702	mevalonate kinase; May be a regulatory site in cholesterol biosynthetic pathway	nuclear transcription factor Y, alpha; Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters, for example in type 1 collagen, albumin and beta-actin genes	0.900
MVK	NFYB	ENSP00000228510	ENSP00000240055	mevalonate kinase; May be a regulatory site in cholesterol biosynthetic pathway	nuclear transcription factor Y, beta; Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters, for example in type 1 collagen, albumin and beta-actin genes	0.902
MVK	NFYC	ENSP00000228510	ENSP00000396620	mevalonate kinase; May be a regulatory site in cholesterol biosynthetic pathway	nuclear transcription factor Y, gamma	0.900
MVK	PMVK	ENSP00000228510	ENSP00000357452	mevalonate kinase; May be a regulatory site in cholesterol biosynthetic pathway	phosphomevalonate kinase	0.973
MVK	SP1	ENSP00000228510	ENSP00000329357	mevalonate kinase; May be a regulatory site in cholesterol biosynthetic pathway	Sp1 transcription factor; Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA d [...]	0.900

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