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RTN4 RTN4 RTN3 RTN3 REEP5 REEP5 BIRC5 BIRC5 RTN1 RTN1 RTN2 RTN2 NUS1 NUS1 EPRS EPRS CDS1 CDS1 C2orf18 C2orf18 CDS2 CDS2
"NUS1" - nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Cooccurence
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[Homology]
Score
NUS1nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae); Acts as a specific receptor for the N-terminus of Nogo- B, a neural and cardiovascular regulator. Regulates the stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol (293 aa)    
Predicted Functional Partners:
BIRC5
baculoviral IAP repeat containing 5 (165 aa)
            score_image   0.800
CDS2
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 (445 aa)
score_image     score_image     score_image   0.712
CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1; Provides CDP-diacylglycerol an important precursor for the synthesis of phosphatidylinositol (PtdIns), phosphatidylglycerol, and cardiolipin. Overexpression may amplify cellular signaling responses from cytokines. May also play an important role in the signal transduction mechanism of retina and neural cells (461 aa)
score_image     score_image     score_image   0.712
C2orf18
chromosome 2 open reading frame 18; Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter (371 aa)
            score_image   0.707
RTN4
reticulon 4 (1192 aa)
            score_image   0.690
RTN3
reticulon 3 (1013 aa)
            score_image   0.681
REEP5
receptor accessory protein 5; May promote functional cell surface expression of olfactory receptors (189 aa)
            score_image   0.680
EPRS
glutamyl-prolyl-tRNA synthetase (1512 aa)
score_image     score_image     score_image   0.672
RTN2
reticulon 2 (545 aa)
            score_image   0.661
RTN1
reticulon 1; May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells (776 aa)
            score_image   0.655
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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