| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ABL1 | EGFR | ENSP00000361423 | ENSP00000275493 | c-abl oncogene 1, non-receptor tyrosine kinase; Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN ( [...] | epidermal growth factor receptor | 0.707 |
| ABL1 | ROS1 | ENSP00000361423 | ENSP00000357494 | c-abl oncogene 1, non-receptor tyrosine kinase; Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN ( [...] | c-ros oncogene 1 , receptor tyrosine kinase; Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activatio [...] | 0.629 |
| ATXN3 | EMC3 | ENSP00000376965 | ENSP00000245046 | ataxin 3 | ER membrane protein complex subunit 3 | 0.634 |
| ATXN3 | GIMAP8 | ENSP00000376965 | ENSP00000305107 | ataxin 3 | GTPase, IMAP family member 8; Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections (By similarity) | 0.585 |
| ATXN3 | MKI67 | ENSP00000376965 | ENSP00000357643 | ataxin 3 | antigen identified by monoclonal antibody Ki-67; Thought to be required for maintaining cell proliferation | 0.639 |
| ATXN3 | ROS1 | ENSP00000376965 | ENSP00000357494 | ataxin 3 | c-ros oncogene 1 , receptor tyrosine kinase; Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activatio [...] | 0.705 |
| EGFR | ABL1 | ENSP00000275493 | ENSP00000361423 | epidermal growth factor receptor | c-abl oncogene 1, non-receptor tyrosine kinase; Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN ( [...] | 0.707 |
| EGFR | ROS1 | ENSP00000275493 | ENSP00000357494 | epidermal growth factor receptor | c-ros oncogene 1 , receptor tyrosine kinase; Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activatio [...] | 0.654 |
| EMC3 | ATXN3 | ENSP00000245046 | ENSP00000376965 | ER membrane protein complex subunit 3 | ataxin 3 | 0.634 |
| EMC3 | GIMAP8 | ENSP00000245046 | ENSP00000305107 | ER membrane protein complex subunit 3 | GTPase, IMAP family member 8; Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections (By similarity) | 0.581 |
| EMC3 | MKI67 | ENSP00000245046 | ENSP00000357643 | ER membrane protein complex subunit 3 | antigen identified by monoclonal antibody Ki-67; Thought to be required for maintaining cell proliferation | 0.581 |
| EMC3 | ROS1 | ENSP00000245046 | ENSP00000357494 | ER membrane protein complex subunit 3 | c-ros oncogene 1 , receptor tyrosine kinase; Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activatio [...] | 0.658 |
| FZD5 | ROS1 | ENSP00000354607 | ENSP00000357494 | frizzled family receptor 5; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both p [...] | c-ros oncogene 1 , receptor tyrosine kinase; Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activatio [...] | 0.662 |
| GIMAP8 | ATXN3 | ENSP00000305107 | ENSP00000376965 | GTPase, IMAP family member 8; Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections (By similarity) | ataxin 3 | 0.585 |
| GIMAP8 | EMC3 | ENSP00000305107 | ENSP00000245046 | GTPase, IMAP family member 8; Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections (By similarity) | ER membrane protein complex subunit 3 | 0.581 |
| GIMAP8 | MKI67 | ENSP00000305107 | ENSP00000357643 | GTPase, IMAP family member 8; Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections (By similarity) | antigen identified by monoclonal antibody Ki-67; Thought to be required for maintaining cell proliferation | 0.538 |
| GIMAP8 | ROS1 | ENSP00000305107 | ENSP00000357494 | GTPase, IMAP family member 8; Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections (By similarity) | c-ros oncogene 1 , receptor tyrosine kinase; Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activatio [...] | 0.635 |
| MKI67 | ATXN3 | ENSP00000357643 | ENSP00000376965 | antigen identified by monoclonal antibody Ki-67; Thought to be required for maintaining cell proliferation | ataxin 3 | 0.639 |
| MKI67 | EMC3 | ENSP00000357643 | ENSP00000245046 | antigen identified by monoclonal antibody Ki-67; Thought to be required for maintaining cell proliferation | ER membrane protein complex subunit 3 | 0.581 |
| MKI67 | GIMAP8 | ENSP00000357643 | ENSP00000305107 | antigen identified by monoclonal antibody Ki-67; Thought to be required for maintaining cell proliferation | GTPase, IMAP family member 8; Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections (By similarity) | 0.538 |
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