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CDK18 CDK18 C16orf80 C16orf80 PWP1 PWP1 NEURL1B NEURL1B COPS5 COPS5 FANK1 FANK1 NEURL NEURL SPATA4 SPATA4 CDK17 CDK17 GZF1 GZF1 ANKRD46 ANKRD46
"FANK1" - fibronectin type III and ankyrin repeat domains 1 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
FANK1fibronectin type III and ankyrin repeat domains 1 (345 aa)    
Predicted Functional Partners:
COPS5
COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis); Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via i [...] (334 aa)
        score_image   score_image   0.922
SPATA4
spermatogenesis associated 4 (305 aa)
            score_image   0.688
GZF1
GDNF-inducible zinc finger protein 1 (711 aa)
        score_image   score_image   0.651
NEURL1B
neuralized homolog 1B (Drosophila); E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands (555 aa)
        score_image   score_image   0.585
NEURL
neuralized homolog (Drosophila); May function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1, thereby regulating the Notch pathway (By similarity) (574 aa)
        score_image   score_image   0.585
PWP1
PWP1 homolog (S. cerevisiae); May play an important role in cell growth and/or transcription (501 aa)
            score_image   0.524
C16orf80
chromosome 16 open reading frame 80 (193 aa)
            score_image   0.489
ANKRD46
ankyrin repeat domain 46 (228 aa)
    score_image           0.451
CDK17
cyclin-dependent kinase 17; May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity) (523 aa)
        score_image   score_image   0.443
CDK18
cyclin-dependent kinase 18; May play a role in signal transduction cascades in terminally differentiated cells (504 aa)
        score_image   score_image   0.440
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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