node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CPNE2 | S100A16 | ENSP00000290776 | ENSP00000357692 | copine II | S100 calcium binding protein A16; Calcium-binding protein. Binds one calcium ion per monomer | 0.659 |
IDH3A | S100A16 | ENSP00000299518 | ENSP00000357692 | isocitrate dehydrogenase 3 (NAD+) alpha | S100 calcium binding protein A16; Calcium-binding protein. Binds one calcium ion per monomer | 0.906 |
IDH3A | SUCLA2 | ENSP00000299518 | ENSP00000367923 | isocitrate dehydrogenase 3 (NAD+) alpha | succinate-CoA ligase, ADP-forming, beta subunit; Catalyzes the ATP-dependent ligation of succinate and CoA to form succinyl-CoA (By similarity) | 0.984 |
IDH3A | SUCLG1 | ENSP00000299518 | ENSP00000377446 | isocitrate dehydrogenase 3 (NAD+) alpha | succinate-CoA ligase, alpha subunit; Catalyzes the ATP- or GTP-dependent ligation of succinate and CoA to form succinyl-CoA. The nature of the beta subunit determines the nucleotide specificity (By similarity) | 0.765 |
OXCT1 | S100A16 | ENSP00000196371 | ENSP00000357692 | 3-oxoacid CoA transferase 1; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity) | S100 calcium binding protein A16; Calcium-binding protein. Binds one calcium ion per monomer | 0.906 |
OXCT1 | SUCLA2 | ENSP00000196371 | ENSP00000367923 | 3-oxoacid CoA transferase 1; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity) | succinate-CoA ligase, ADP-forming, beta subunit; Catalyzes the ATP-dependent ligation of succinate and CoA to form succinyl-CoA (By similarity) | 0.912 |
OXCT1 | SUCLG1 | ENSP00000196371 | ENSP00000377446 | 3-oxoacid CoA transferase 1; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity) | succinate-CoA ligase, alpha subunit; Catalyzes the ATP- or GTP-dependent ligation of succinate and CoA to form succinyl-CoA. The nature of the beta subunit determines the nucleotide specificity (By similarity) | 0.953 |
OXCT1 | TMEM9 | ENSP00000196371 | ENSP00000356298 | 3-oxoacid CoA transferase 1; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity) | transmembrane protein 9; May be involved in intracellular transport | 0.905 |
OXCT1 | VAPB | ENSP00000196371 | ENSP00000417175 | 3-oxoacid CoA transferase 1; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity) | VAMP (vesicle-associated membrane protein)-associated protein B and C; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation | 0.896 |
S100A14 | S100A16 | ENSP00000340463 | ENSP00000357692 | S100 calcium binding protein A14; Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium | S100 calcium binding protein A16; Calcium-binding protein. Binds one calcium ion per monomer | 0.947 |
S100A16 | CPNE2 | ENSP00000357692 | ENSP00000290776 | S100 calcium binding protein A16; Calcium-binding protein. Binds one calcium ion per monomer | copine II | 0.659 |
S100A16 | IDH3A | ENSP00000357692 | ENSP00000299518 | S100 calcium binding protein A16; Calcium-binding protein. Binds one calcium ion per monomer | isocitrate dehydrogenase 3 (NAD+) alpha | 0.906 |
S100A16 | OXCT1 | ENSP00000357692 | ENSP00000196371 | S100 calcium binding protein A16; Calcium-binding protein. Binds one calcium ion per monomer | 3-oxoacid CoA transferase 1; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity) | 0.906 |
S100A16 | S100A14 | ENSP00000357692 | ENSP00000340463 | S100 calcium binding protein A16; Calcium-binding protein. Binds one calcium ion per monomer | S100 calcium binding protein A14; Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium | 0.947 |
S100A16 | SUCLA2 | ENSP00000357692 | ENSP00000367923 | S100 calcium binding protein A16; Calcium-binding protein. Binds one calcium ion per monomer | succinate-CoA ligase, ADP-forming, beta subunit; Catalyzes the ATP-dependent ligation of succinate and CoA to form succinyl-CoA (By similarity) | 0.909 |
S100A16 | SUCLG1 | ENSP00000357692 | ENSP00000377446 | S100 calcium binding protein A16; Calcium-binding protein. Binds one calcium ion per monomer | succinate-CoA ligase, alpha subunit; Catalyzes the ATP- or GTP-dependent ligation of succinate and CoA to form succinyl-CoA. The nature of the beta subunit determines the nucleotide specificity (By similarity) | 0.906 |
S100A16 | TMED10 | ENSP00000357692 | ENSP00000303145 | S100 calcium binding protein A16; Calcium-binding protein. Binds one calcium ion per monomer | transmembrane emp24-like trafficking protein 10 (yeast); Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act togther with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipi [...] | 0.898 |
S100A16 | TMEM9 | ENSP00000357692 | ENSP00000356298 | S100 calcium binding protein A16; Calcium-binding protein. Binds one calcium ion per monomer | transmembrane protein 9; May be involved in intracellular transport | 0.858 |
S100A16 | UBA52 | ENSP00000357692 | ENSP00000388107 | S100 calcium binding protein A16; Calcium-binding protein. Binds one calcium ion per monomer | ubiquitin A-52 residue ribosomal protein fusion product 1 | 0.662 |
S100A16 | VAPB | ENSP00000357692 | ENSP00000417175 | S100 calcium binding protein A16; Calcium-binding protein. Binds one calcium ion per monomer | VAMP (vesicle-associated membrane protein)-associated protein B and C; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation | 0.898 |