node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EVPL | FLG | ENSP00000301607 | ENSP00000357789 | envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments | filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis | 0.511 |
EVPL | IVL | ENSP00000301607 | ENSP00000357753 | envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments | involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia (By similarity) | 0.852 |
EVPL | KRT1 | ENSP00000301607 | ENSP00000252244 | envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments | keratin 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein kinase C (RACK1/GNB2L1). In complex with C1QBP is a high affinty receptor for kininogen-1/HMWK | 0.678 |
EVPL | KRT16 | ENSP00000301607 | ENSP00000301653 | envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments | keratin 16 | 0.581 |
EVPL | LOR | ENSP00000301607 | ENSP00000357731 | envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments | loricrin; Major keratinocyte cell envelope protein | 0.827 |
EVPL | SPRR3 | ENSP00000301607 | ENSP00000295367 | envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments | small proline-rich protein 3 | 0.598 |
FLG | EVPL | ENSP00000357789 | ENSP00000301607 | filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis | envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments | 0.511 |
FLG | IVL | ENSP00000357789 | ENSP00000357753 | filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis | involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia (By similarity) | 0.980 |
FLG | KRT1 | ENSP00000357789 | ENSP00000252244 | filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis | keratin 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein kinase C (RACK1/GNB2L1). In complex with C1QBP is a high affinty receptor for kininogen-1/HMWK | 0.777 |
FLG | KRT16 | ENSP00000357789 | ENSP00000301653 | filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis | keratin 16 | 0.972 |
FLG | LOR | ENSP00000357789 | ENSP00000357731 | filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis | loricrin; Major keratinocyte cell envelope protein | 0.980 |
FLG | SPRR3 | ENSP00000357789 | ENSP00000295367 | filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis | small proline-rich protein 3 | 0.517 |
GATA3 | JUN | ENSP00000368632 | ENSP00000360266 | GATA binding protein 3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5’-AGATAG-3’ | jun proto-oncogene; Transcription factor that recognizes and binds to the enhancer heptamer motif 5’-TGA[CG]TCA-3’. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation | 0.740 |
GATA3 | LOR | ENSP00000368632 | ENSP00000357731 | GATA binding protein 3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5’-AGATAG-3’ | loricrin; Major keratinocyte cell envelope protein | 0.844 |
GATA3 | YY1 | ENSP00000368632 | ENSP00000262238 | GATA binding protein 3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5’-AGATAG-3’ | YY1 transcription factor; Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5’-CCGCCATNTT-3’; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repre [...] | 0.904 |
IVL | EVPL | ENSP00000357753 | ENSP00000301607 | involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia (By similarity) | envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments | 0.852 |
IVL | FLG | ENSP00000357753 | ENSP00000357789 | involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia (By similarity) | filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis | 0.980 |
IVL | JUN | ENSP00000357753 | ENSP00000360266 | involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia (By similarity) | jun proto-oncogene; Transcription factor that recognizes and binds to the enhancer heptamer motif 5’-TGA[CG]TCA-3’. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation | 0.896 |
IVL | KRT1 | ENSP00000357753 | ENSP00000252244 | involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia (By similarity) | keratin 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein kinase C (RACK1/GNB2L1). In complex with C1QBP is a high affinty receptor for kininogen-1/HMWK | 0.908 |
IVL | KRT16 | ENSP00000357753 | ENSP00000301653 | involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia (By similarity) | keratin 16 | 0.972 |