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STRINGSTRING
KRTAP4-2 KRTAP4-2 OTX1 OTX1 LELP1 LELP1 LCE2A LCE2A LCE3D LCE3D LCE6A LCE6A ELOVL6 ELOVL6 LCE4A LCE4A LCE3A LCE3A C1orf68 C1orf68 LCE1E LCE1E
"LCE2A" - late cornified envelope 2A in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LCE2Alate cornified envelope 2A; Precursors of the cornified envelope of the stratum corneum (106 aa)    
Predicted Functional Partners:
LELP1
late cornified envelope-like proline-rich 1 (98 aa)
            score_image   0.757
OTX1
orthodenticle homeobox 1; Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS)- 5’-TCTAATCCC-3’ (354 aa)
        score_image       0.756
ELOVL6
ELOVL fatty acid elongase 6; Condensing enzyme that catalyzes the synthesis of saturated and monounsaturated fatty acids. Highest activity toward C16-0 acyl-CoAs (265 aa)
            score_image   0.750
LCE4A
late cornified envelope 4A; Precursors of the cornified envelope of the stratum corneum (99 aa)
            score_image   0.725
LCE1E
late cornified envelope 1E; Precursors of the cornified envelope of the stratum corneum (118 aa)
            score_image   0.583
LCE6A
late cornified envelope 6A; Precursors of the cornified envelope of the stratum corneum (By similarity) (80 aa)
            score_image   0.569
C1orf68
chromosome 1 open reading frame 68 (250 aa)
            score_image   0.539
KRTAP4-2
keratin associated protein 4-2; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins (136 aa)
        score_image       0.531
LCE3A
late cornified envelope 3A; Precursors of the cornified envelope of the stratum corneum (89 aa)
            score_image   0.509
LCE3D
late cornified envelope 3D; Precursors of the cornified envelope of the stratum corneum (92 aa)
            score_image   0.507
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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