Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
ANKRD18A ANKRD18A SPRY1 SPRY1 GLRX3 GLRX3 LCE3C LCE3C LCE2D LCE2D ELOVL6 ELOVL6 MAGEA11 MAGEA11 LCE3A LCE3A LCE3D LCE3D LCE2C LCE2C ANKRD18B ANKRD18B
"LCE2D" - late cornified envelope 2D in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LCE2Dlate cornified envelope 2D; Precursors of the cornified envelope of the stratum corneum (110 aa)    
Predicted Functional Partners:
ELOVL6
ELOVL fatty acid elongase 6; Condensing enzyme that catalyzes the synthesis of saturated and monounsaturated fatty acids. Highest activity toward C16-0 acyl-CoAs (265 aa)
            score_image   0.750
SPRY1
sprouty homolog 1, antagonist of FGF signaling (Drosophila); May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis (319 aa)
        score_image       0.730
LCE2C
late cornified envelope 2C; Precursors of the cornified envelope of the stratum (110 aa)
            score_image   0.588
LCE3A
late cornified envelope 3A; Precursors of the cornified envelope of the stratum corneum (89 aa)
            score_image   0.508
LCE3D
late cornified envelope 3D; Precursors of the cornified envelope of the stratum corneum (92 aa)
            score_image   0.506
MAGEA11
melanoma antigen family A, 11; Acts as androgen receptor co-regulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression (429 aa)
            score_image   0.505
GLRX3
glutaredoxin 3; Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). May play a role in regulating the function of the thioredoxin system. Does not posses any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity (335 aa)
        score_image       0.503
ANKRD18B
ankyrin repeat domain 18B (1011 aa)
            score_image   0.475
LCE3C
late cornified envelope 3C; Precursors of the cornified envelope of the stratum corneum (94 aa)
            score_image   0.472
ANKRD18A
ankyrin repeat domain 18A (992 aa)
            score_image   0.418
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (36%)