node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARHGEF2 | TDRKH | ENSP00000354837 | ENSP00000357812 | Rho/Rac guanine nucleotide exchange factor (GEF) 2; Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed-9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras- GTPases. Forms an intracellular sensing sys [...] | tudor and KH domain containing | 0.594 |
CASD1 | MTHFD2L | ENSP00000297273 | ENSP00000379108 | CAS1 domain containing 1 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | 0.480 |
CASD1 | TDRKH | ENSP00000297273 | ENSP00000357812 | CAS1 domain containing 1 | tudor and KH domain containing | 0.597 |
CLNS1A | TDRKH | ENSP00000433919 | ENSP00000357812 | chloride channel, nucleotide-sensitive, 1A; The interaction with Sm proteins inhibits their assembly on U RNA and interferes with snRNP biogenesis. Inhibits the binding of survival motor neuron protein (SMN) to Sm proteins. May participate in cellular volume control by activation of a swelling-induced chloride conductance pathway | tudor and KH domain containing | 0.889 |
MOV10L1 | PIWIL1 | ENSP00000262794 | ENSP00000245255 | Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse) | piwi-like 1 (Drosophila); Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer- independent mechanism and are primarily derived from transposons and ot [...] | 0.952 |
MOV10L1 | PIWIL2 | ENSP00000262794 | ENSP00000349208 | Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse) | piwi-like 2 (Drosophila) | 0.920 |
MOV10L1 | PIWIL3 | ENSP00000262794 | ENSP00000330031 | Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse) | piwi-like 3 (Drosophila); May play a role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequ [...] | 0.528 |
MOV10L1 | PIWIL4 | ENSP00000262794 | ENSP00000299001 | Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse) | piwi-like 4 (Drosophila); Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated [...] | 0.952 |
MOV10L1 | TDRKH | ENSP00000262794 | ENSP00000357812 | Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse) | tudor and KH domain containing | 0.603 |
MTHFD2L | CASD1 | ENSP00000379108 | ENSP00000297273 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | CAS1 domain containing 1 | 0.480 |
MTHFD2L | TDRKH | ENSP00000379108 | ENSP00000357812 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | tudor and KH domain containing | 0.562 |
PIWIL1 | MOV10L1 | ENSP00000245255 | ENSP00000262794 | piwi-like 1 (Drosophila); Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer- independent mechanism and are primarily derived from transposons and ot [...] | Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse) | 0.952 |
PIWIL1 | STK31 | ENSP00000245255 | ENSP00000348132 | piwi-like 1 (Drosophila); Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer- independent mechanism and are primarily derived from transposons and ot [...] | serine/threonine kinase 31 | 0.472 |
PIWIL1 | TDRKH | ENSP00000245255 | ENSP00000357812 | piwi-like 1 (Drosophila); Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer- independent mechanism and are primarily derived from transposons and ot [...] | tudor and KH domain containing | 0.964 |
PIWIL2 | MOV10L1 | ENSP00000349208 | ENSP00000262794 | piwi-like 2 (Drosophila) | Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse) | 0.920 |
PIWIL2 | PIWIL4 | ENSP00000349208 | ENSP00000299001 | piwi-like 2 (Drosophila) | piwi-like 4 (Drosophila); Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated [...] | 0.411 |
PIWIL2 | TDRKH | ENSP00000349208 | ENSP00000357812 | piwi-like 2 (Drosophila) | tudor and KH domain containing | 0.679 |
PIWIL3 | MOV10L1 | ENSP00000330031 | ENSP00000262794 | piwi-like 3 (Drosophila); May play a role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequ [...] | Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse) | 0.528 |
PIWIL3 | STK31 | ENSP00000330031 | ENSP00000348132 | piwi-like 3 (Drosophila); May play a role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequ [...] | serine/threonine kinase 31 | 0.560 |
PIWIL3 | TDRKH | ENSP00000330031 | ENSP00000357812 | piwi-like 3 (Drosophila); May play a role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequ [...] | tudor and KH domain containing | 0.599 |