METTL10 protein (Homo sapiens) - STRING network view

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Score

METTL10

methyltransferase like 10 (291 aa)

Predicted Functional Partners:

TREX1

0.521

TREX2

0.521

EEF1A1

0.511

METTL7B

0.508

DMAP1

0.479

NIP7

0.433

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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MFA: multi-fasta format - containing the aminoacid sequences in the network

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DMAP1	METTL10	ENSP00000312697	ENSP00000357829	DNA methyltransferase 1 associated protein 1; Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX- mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucl [...]	methyltransferase like 10	0.479
EEF1A1	METTL10	ENSP00000330054	ENSP00000357829	eukaryotic translation elongation factor 1 alpha 1; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production	methyltransferase like 10	0.511
METTL10	DMAP1	ENSP00000357829	ENSP00000312697	methyltransferase like 10	DNA methyltransferase 1 associated protein 1; Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX- mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucl [...]	0.479
METTL10	EEF1A1	ENSP00000357829	ENSP00000330054	methyltransferase like 10	eukaryotic translation elongation factor 1 alpha 1; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production	0.511
METTL10	METTL7B	ENSP00000357829	ENSP00000377796	methyltransferase like 10	methyltransferase like 7B; Probable methyltransferase (By similarity)	0.508
METTL10	NIP7	ENSP00000357829	ENSP00000254940	methyltransferase like 10	nuclear import 7 homolog (S. cerevisiae); Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly	0.433
METTL10	TREX1	ENSP00000357829	ENSP00000390478	methyltransferase like 10	three prime repair exonuclease 1; Exonuclease with a preference for double stranded DNA with mismatched 3’ termini. May play a role in DNA repair	0.521
METTL10	TREX2	ENSP00000357829	ENSP00000333441	methyltransferase like 10	three prime repair exonuclease 2; Exonuclease with a preference for double stranded DNA with mismatched 3’ termini. May play a role in DNA repair	0.521
METTL7B	METTL10	ENSP00000377796	ENSP00000357829	methyltransferase like 7B; Probable methyltransferase (By similarity)	methyltransferase like 10	0.508
NIP7	METTL10	ENSP00000254940	ENSP00000357829	nuclear import 7 homolog (S. cerevisiae); Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly	methyltransferase like 10	0.433
TREX1	METTL10	ENSP00000390478	ENSP00000357829	three prime repair exonuclease 1; Exonuclease with a preference for double stranded DNA with mismatched 3’ termini. May play a role in DNA repair	methyltransferase like 10	0.521
TREX2	METTL10	ENSP00000333441	ENSP00000357829	three prime repair exonuclease 2; Exonuclease with a preference for double stranded DNA with mismatched 3’ termini. May play a role in DNA repair	methyltransferase like 10	0.521

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