node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
RACGAP1 | SLC16A10 | ENSP00000309871 | ENSP00000357844 | Rac GTPase activating protein 1; Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase acti [...] | solute carrier family 16, member 10 (aromatic amino acid transporter); Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity) | 0.576 |
RACGAP1 | TOP2A | ENSP00000309871 | ENSP00000411532 | Rac GTPase activating protein 1; Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase acti [...] | topoisomerase (DNA) II alpha 170kDa | 0.661 |
RACGAP1 | UBC | ENSP00000309871 | ENSP00000344818 | Rac GTPase activating protein 1; Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase acti [...] | ubiquitin C | 0.975 |
SLC16A10 | RACGAP1 | ENSP00000357844 | ENSP00000309871 | solute carrier family 16, member 10 (aromatic amino acid transporter); Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity) | Rac GTPase activating protein 1; Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase acti [...] | 0.576 |
SLC16A10 | SLC23A1 | ENSP00000357844 | ENSP00000302851 | solute carrier family 16, member 10 (aromatic amino acid transporter); Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity) | solute carrier family 23 (nucleobase transporters), member 1; Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate | 0.522 |
SLC16A10 | SLC23A2 | ENSP00000357844 | ENSP00000344322 | solute carrier family 16, member 10 (aromatic amino acid transporter); Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity) | solute carrier family 23 (nucleobase transporters), member 2; Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate | 0.521 |
SLC16A10 | SLC25A17 | ENSP00000357844 | ENSP00000390722 | solute carrier family 16, member 10 (aromatic amino acid transporter); Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity) | solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17; Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extend for nicotinamide adenine dinucleotide (NAD(+)), adenosine diphosphate (ADP) and adenosine 3’,5’- diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD(+) from the cytosol into the peroxisomal matrix by a counter- exchange mechanism. Inhibited by pyridoxal 5’-phosphate and ba [...] | 0.515 |
SLC16A10 | SLC39A12 | ENSP00000357844 | ENSP00000366586 | solute carrier family 16, member 10 (aromatic amino acid transporter); Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity) | solute carrier family 39 (zinc transporter), member 12 | 0.521 |
SLC16A10 | SLC7A6 | ENSP00000357844 | ENSP00000219343 | solute carrier family 16, member 10 (aromatic amino acid transporter); Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity) | solute carrier family 7 (amino acid transporter light chain, y+L system), member 6; Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arg [...] | 0.531 |
SLC16A10 | SLC7A8 | ENSP00000357844 | ENSP00000320378 | solute carrier family 16, member 10 (aromatic amino acid transporter); Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity) | solute carrier family 7 (amino acid transporter light chain, L system), member 8; Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylme [...] | 0.625 |
SLC16A10 | SLCO1C1 | ENSP00000357844 | ENSP00000370964 | solute carrier family 16, member 10 (aromatic amino acid transporter); Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity) | solute carrier organic anion transporter family, member 1C1; Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency. May play a signifiant role in regulating T4 flux into and out of the brain (By similarity) | 0.719 |
SLC16A10 | TOP2A | ENSP00000357844 | ENSP00000411532 | solute carrier family 16, member 10 (aromatic amino acid transporter); Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity) | topoisomerase (DNA) II alpha 170kDa | 0.508 |
SLC16A10 | UBC | ENSP00000357844 | ENSP00000344818 | solute carrier family 16, member 10 (aromatic amino acid transporter); Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity) | ubiquitin C | 0.505 |
SLC23A1 | SLC16A10 | ENSP00000302851 | ENSP00000357844 | solute carrier family 23 (nucleobase transporters), member 1; Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate | solute carrier family 16, member 10 (aromatic amino acid transporter); Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity) | 0.522 |
SLC23A1 | SLC25A17 | ENSP00000302851 | ENSP00000390722 | solute carrier family 23 (nucleobase transporters), member 1; Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate | solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17; Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extend for nicotinamide adenine dinucleotide (NAD(+)), adenosine diphosphate (ADP) and adenosine 3’,5’- diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD(+) from the cytosol into the peroxisomal matrix by a counter- exchange mechanism. Inhibited by pyridoxal 5’-phosphate and ba [...] | 0.477 |
SLC23A1 | SLC39A12 | ENSP00000302851 | ENSP00000366586 | solute carrier family 23 (nucleobase transporters), member 1; Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate | solute carrier family 39 (zinc transporter), member 12 | 0.507 |
SLC23A2 | SLC16A10 | ENSP00000344322 | ENSP00000357844 | solute carrier family 23 (nucleobase transporters), member 2; Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate | solute carrier family 16, member 10 (aromatic amino acid transporter); Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity) | 0.521 |
SLC23A2 | SLC25A17 | ENSP00000344322 | ENSP00000390722 | solute carrier family 23 (nucleobase transporters), member 2; Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate | solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17; Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extend for nicotinamide adenine dinucleotide (NAD(+)), adenosine diphosphate (ADP) and adenosine 3’,5’- diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD(+) from the cytosol into the peroxisomal matrix by a counter- exchange mechanism. Inhibited by pyridoxal 5’-phosphate and ba [...] | 0.476 |
SLC23A2 | SLC39A12 | ENSP00000344322 | ENSP00000366586 | solute carrier family 23 (nucleobase transporters), member 2; Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate | solute carrier family 39 (zinc transporter), member 12 | 0.495 |
SLC23A2 | UBC | ENSP00000344322 | ENSP00000344818 | solute carrier family 23 (nucleobase transporters), member 2; Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate | ubiquitin C | 0.483 |