AMD1 protein (Homo sapiens) - STRING network view

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AMD1

adenosylmethionine decarboxylase 1 (334 aa)

Predicted Functional Partners:

SRM

0.987

SMS

0.980

ODC1

0.946

MAT1A

0.932

ADC

0.927

MAT2A

0.917

MAT2B

0.903

DNMT1

0.902

DNMT3B

0.900

DNMT3A

0.900

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADC	AMD1	ENSP00000294517	ENSP00000357880	arginine decarboxylase	adenosylmethionine decarboxylase 1	0.927
ADC	MAT1A	ENSP00000294517	ENSP00000361280	arginine decarboxylase	methionine adenosyltransferase I, alpha; Catalyzes the formation of S-adenosylmethionine from methionine and ATP (By similarity)	0.476
ADC	SMS	ENSP00000294517	ENSP00000385746	arginine decarboxylase	spermine synthase; Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM)	0.821
ADC	SRM	ENSP00000294517	ENSP00000366156	arginine decarboxylase	spermidine synthase; Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine	0.917
AMD1	ADC	ENSP00000357880	ENSP00000294517	adenosylmethionine decarboxylase 1	arginine decarboxylase	0.927
AMD1	DNMT1	ENSP00000357880	ENSP00000352516	adenosylmethionine decarboxylase 1	DNA (cytosine-5-)-methyltransferase 1; Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In [...]	0.902
AMD1	DNMT3A	ENSP00000357880	ENSP00000264709	adenosylmethionine decarboxylase 1	DNA (cytosine-5-)-methyltransferase 3 alpha; Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Can actively [...]	0.900
AMD1	DNMT3B	ENSP00000357880	ENSP00000328547	adenosylmethionine decarboxylase 1	DNA (cytosine-5-)-methyltransferase 3 beta	0.900
AMD1	MAT1A	ENSP00000357880	ENSP00000361280	adenosylmethionine decarboxylase 1	methionine adenosyltransferase I, alpha; Catalyzes the formation of S-adenosylmethionine from methionine and ATP (By similarity)	0.932
AMD1	MAT2A	ENSP00000357880	ENSP00000303147	adenosylmethionine decarboxylase 1	methionine adenosyltransferase II, alpha; Catalyzes the formation of S-adenosylmethionine from methionine and ATP (By similarity)	0.917
AMD1	MAT2B	ENSP00000357880	ENSP00000325425	adenosylmethionine decarboxylase 1	methionine adenosyltransferase II, beta	0.903
AMD1	ODC1	ENSP00000357880	ENSP00000234111	adenosylmethionine decarboxylase 1	ornithine decarboxylase 1	0.946
AMD1	SMS	ENSP00000357880	ENSP00000385746	adenosylmethionine decarboxylase 1	spermine synthase; Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM)	0.980
AMD1	SRM	ENSP00000357880	ENSP00000366156	adenosylmethionine decarboxylase 1	spermidine synthase; Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine	0.987
DNMT1	AMD1	ENSP00000352516	ENSP00000357880	DNA (cytosine-5-)-methyltransferase 1; Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In [...]	adenosylmethionine decarboxylase 1	0.902
DNMT1	DNMT3A	ENSP00000352516	ENSP00000264709	DNA (cytosine-5-)-methyltransferase 1; Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In [...]	DNA (cytosine-5-)-methyltransferase 3 alpha; Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Can actively [...]	0.999
DNMT1	DNMT3B	ENSP00000352516	ENSP00000328547	DNA (cytosine-5-)-methyltransferase 1; Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In [...]	DNA (cytosine-5-)-methyltransferase 3 beta	0.999
DNMT1	MAT1A	ENSP00000352516	ENSP00000361280	DNA (cytosine-5-)-methyltransferase 1; Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In [...]	methionine adenosyltransferase I, alpha; Catalyzes the formation of S-adenosylmethionine from methionine and ATP (By similarity)	0.949
DNMT1	MAT2A	ENSP00000352516	ENSP00000303147	DNA (cytosine-5-)-methyltransferase 1; Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In [...]	methionine adenosyltransferase II, alpha; Catalyzes the formation of S-adenosylmethionine from methionine and ATP (By similarity)	0.939
DNMT1	MAT2B	ENSP00000352516	ENSP00000325425	DNA (cytosine-5-)-methyltransferase 1; Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In [...]	methionine adenosyltransferase II, beta	0.917

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